Curing Chronic Hepatitis C: A Cost Comparison of the Combination Simeprevir Plus Sofosbuvir vs. Protease-Inhibitor-Based Triple Therapy

Título del documento: Curing Chronic Hepatitis C: A Cost Comparison of the Combination Simeprevir Plus Sofosbuvir vs. Protease-Inhibitor-Based Triple Therapy
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000407814
ISSN: 1665-2681
Autores: 1
Instituciones: 1University Of Colorado Hospital, Department of Pharmacy, Aurora, Colorado. Estados Unidos de América
2University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado. Estados Unidos de América
3University of Colorado Denver, School of Medicine, Denver, Colorado. Estados Unidos de América
Periodo: May-Jun
Volumen: 16
Número: 3
Paginación: 366-374
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Interferon-free, multi-direct acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection is highly effective and well tolerated, but costly. To gain perspective on the evolving economics of HCV therapy, we compared the cost per cure of a multi-DAA regimen with the prior standard of triple therapy. Material and methods. Material and methods. Patients infected with HCV genotype 1 who were treated through the University of Colorado Hepatology Clinic between May 2011 and December 2014 comprised the study population. The multi-DAA regimen of simeprevir plus sofosbuvir (SMV/SOF) was compared to the triple therapy regimen consisting of peginterferon and ribavirin, with either boceprevir or telaprevir (TT). Sustained-virologic response (SVR) rates, total costs per treatment and adverse events were recorded. Total cost per SVR were compared for the two treatments, controlling for patient demographics and clinical characteristics. Results. Results. Results. One hundred eighty-three patients received SMV/SOF (n = 70) or TT (n = 113). Patients receiving SMV/SOF were older, more treatment experienced, and had a higher stage of fibrosis. SVRs were 86% and 59%, average total costs per patient were $152,775 and $95,943, and average total costs per SVR were $178,237 vs. $161,813.49 for SMV/SOF and TT groups, respectively. Medication costs accounted for 98% of SMV/SOF and 85% of TT treatment costs. Conclusion. Conclusion. The Conclusion. high cure rate of multi-DAA treatment of HCV is offset by the high costs of the DAAs, such that the cost per cure from TT to multi-DAA therapy has been relatively constant. In order to cure more patients, either additional financial resources will need to be allocated to the treatment of HCV or drug costs will need to be reduced
Disciplinas: Medicina
Palabras clave: Farmacología,
Terapéutica y rehabilitación,
Hepatitis crónica,
Hepatitis C,
Terapia antiviral,
Terapia triple de inhibidores de proteasas,
Costo de tratamiento
Keyword: Medicine,
Therapeutics and rehabilitation,
Chronic hepatitis,
Hepatitis C,
Antiviral therapy,
Protease-inhibitor triple therapy,
Treatment cost
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