| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413457 |
| ISSN: | 1665-2681 |
| Autores: | Kawanaka, Miwa1 Nishino, Ken1 Nakamura, Jun1 Urata, Noriyo1 Oka, Takahito1 Goto, Daisuke1 Suehiro, Mitsuhiko1 Kawamoto, Hirofumi1 Yamada, Gotaro1 |
| Instituciones: | 1Kawasaki Medical School, Kawasaki Hospital, Okayama. Japón |
| Año: | 2015 |
| Periodo: | Nov-Dic |
| Volumen: | 14 |
| Número: | 6 |
| Paginación: | 837-844 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Diagnosis of non-alcoholic fatty liver disease (NAFLD) is limited by the need for liver biopsies. Serum cytokeratin 18 (CK-18) levels have been investigated as potential biomarkers for the presence of NAFLD and non-alcoholic steatohepatitis (NASH). Herein, we assessed the correlation between CK-18 levels and NAFLD progression. Material and methods. Serum CK-18 levels were estimated using the M30 antibody enzyme-linked immunosorbent assay in 147 patients diagnosed with NAFLD. In 72 patients, disease progression was evaluated by repeated liver biopsy, which was conducted after 4.3 ± 2.6 years. The relationship between the CK-18 levels and liver histological findings was assessed. Results. The CK-18 levels were useful for identifying NAFLD patients with NAFLD activity scores (NAS) ≥ 5 (NAS ≥ 5 vs. ≤ 4: 675.1 U/L vs. 348.7 U/L; p < 0.0001). A cut-off value of 375 U/L was calculated using the receiver operating characteristic curve approach, with a specificity and sensitivity of 81.5 and 65%, respectively, for the diagnosis of NASH. Among the 72 patients who underwent repeated liver biopsy, 11 patients with a progressed NAS also had significantly increased serum CK-18 levels (p < 0.01); in 30 patients with an improved NAS, there was a significant improvement in the mean CK-18 levels (p < 0.0001). The 31 patients with static NAS had static CK-18 levels. Conclusions. In conclusion, serum CK-18 levels can predict NAS ≥ 5 in NAFLD patients. In NAFLD patients, serum CK-18 levels reflect NAS values and correlate with histological changes, and they appear to be useful indicators of progression and improvement |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Gastroenterología, Hígado graso no alcohólico, Indicadores pronósticos, Citoqueratina 18, Fibrosis hepática |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Non alcoholic fatty liver, Prognosis indicators, Cytokeratin 18, Liver fibrosis |
| Texte intégral: | Texto completo (Ver PDF) |
