| Revue: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436069 |
| ISSN: | 0001-3765 |
| Autores: | Maneewattanapinyo, Pattwat1 Yeesamun, Alisa1 Watthana, Fueangfan1 Panrat, Kamon2 Pichayakorn, Wiwat3 Suksaeree, Jirapornchai1 |
| Instituciones: | 1Rangsit University, College of Pharmacy, Muang, Pathum Thani. Tailandia 2Prince of Songkla University, Pharmaceutical Laboratory Service Center, Hat-Yai, Songkhla. Tailandia 3Prince of Songkla University, Faculty of Pharmaceutical Sciences, Hat-Yai, Songkhla. Tailandia |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The objectives of this study are to prepare a 5 wt% lidocaine/aspirin ionic liquid drug-loaded gelatin/polyvinyl alcohol composite film using a freeze-thaw procedure and to evaluate their physicochemical characteristics, in vitro drug release, and stability. Lidocaine/aspirin ionic liquid drugs can be prepared by an ion-pair reaction between the hydrochloride salts of lidocaine and the sodium salts of aspirin, which showed a significant change in their thermal properties when compared to those pure drugs. The results showed that a transdermal patch could feasibly be used in pharmaceutical transdermal patches with good physicochemical properties. A chemical interaction between the drug and polymer base was not found. Decomposition of the lidocaine/aspirin ionic liquid drug was found in the patch; however, the properties of the patch were not changed after drug loading. The patch controlled the drug release and showed good stability during the studied period of three months when kept at 4°C more than at ambient temperature and 45°C |
| Disciplinas: | Medicina |
| Palabras clave: | Química farmacéutica, Líquidos iónicos, Lidocaína, Aspirina, Parches transdérmicos |
| Keyword: | Medicinal chemistry, Ionic liquids, Lidocaine, Aspirin, Transdermal patches |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
