| Revue: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436310 |
| ISSN: | 0001-3765 |
| Autores: | Haiyuan, Yu1 Shen, Xueqing1 Liu, Dan2 Hong, Minhua2 Lu, Yanhua1 |
| Instituciones: | 1East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai. China 2Shanghai Inoherb Cosmetics Limited Company, Technology Center, Shanghai. China |
| Año: | 2019 |
| Volumen: | 91 |
| Número: | 4 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protective performance against skin aging was assayed by co-culturing with skin cells in this work. Results showed that β-sitosterol promoted the biosynthesis of hyaluronic acid by increasing the expression of hyaluronic acid synthases in fibroblasts and enhanced the expression of skin barrier functional proteins including aquaporin 3, loricrin, filaggrin and involucrin in keratinocytes, which conduced to the moisture retention within skin. Moreover, vermicularin might function as an anti-wrinkle agent by preventing the loss of collagen type I. Specifically, vermicularin reduced the amount of reactive oxygen species within hydrogen-peroxide-induced fibroblasts; together with suppressing the activation of mitogen-activated protein kinases, it could inhibit the production of matrix metalloproteinases-1. The present research will contribute to the development of the compounds as anti-aging ingredients for future applications in cosmetic formulations and functional food as well as promote further studies of raw materials containing alike compounds |
| Disciplinas: | Química |
| Palabras clave: | Farmacología, Cosmetología, Productos naturales, Envejecimiento de la piel, Humectantes, Beta-sitosterol, Vermicularina, Líquenes, Thamnolia vermicularis, Icmadophilaceae |
| Keyword: | Pharmacology, Cosmetology, Natural products, Skin aging, Moisturizing agents, Beta-sitosterol, Vermicularin, Lichens, Thamnolia vermicularis, Icmadophilaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
