The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Título del documento: The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Revue: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000409018
ISSN: 0001-3765
Autores: 1
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Instituciones: 1Universidade do Extremo Sul Catarinense, Unidade Academica de Ciencias da Saude, Criciuma, Santa Catarina. Brasil
Año:
Periodo: Jun
Volumen: 89
Número: 2
Paginación: 1133-1142
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the hyperlocomotion induced by ket. Ket also showed an increase of AChE activity within the prefrontal cortex and striatum prevented by AA. Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder
Disciplinas: Medicina
Palabras clave: Farmacología,
Medicina experimental,
Psiquiatría,
Esquizofrenia,
Hipermovilidad,
Acido ascórbico,
Modelos animales
Keyword: Medicine,
Experimental medicine,
Pharmacology,
Psychiatry,
Schizophrenia,
Hypermobility,
Ascorbic acid,
Animal models
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