| Revue: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000424435 |
| ISSN: | 0001-3765 |
| Autores: | Cruz, Wanise M. Souza1 Guimaraes, Sheila M.S2 Maciel, Gabrielle C2 Huguenin, Ana Beatriz A2 Carvalho, Monicque E.M. de2 Costa, Barbara O2 Silva, Geisiane A. da2 Colafranceschi, Alexandre S4 Scalco, Fernanda B3 Ribeiro, Marcia1 |
| Instituciones: | 1Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Rio de Janeiro. Brasil 2Universidade Federal Fluminense, Faculdade de Nutricao, Niteroi, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Quimica, Rio de Janeiro. Brasil 4Instituto Nacional de Cardiologia, Departamento de Cirurgia, Rio de Janeiro. Brasil |
| Año: | 2018 |
| Periodo: | Sep |
| Volumen: | 90 |
| Número: | 3 |
| Paginación: | 3099-3104 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Coronary artery bypass grafting reduces plasma L-carnitine and may impair the production of myocardial energy. L-carnitine supplementation may elevate plasma L-carnitine and increase cardiac mechanical efficiency. The objective of this study was to verify the recovery of preoperative plasma LC in patients with heart failure undergoing coronary artery bypass grafting supplemented with a daily oral dose of 50 mg / kg. Volunteers with ischemic heart failure who underwent surgery were randomized into a supplemented group (A-received 50 mg / kg L-carnitine) or placebo group (B) for 60 days. Supplementation was started on the third postoperative day. The spectrophotometric enzymatic method was used to quantify plasma L-carnitine. In the preoperative period, both groups had plasma L-carnitine adequate to the reference range (18.9-71.1 μM). On the second postoperative day, there was a reduction in plasma L-carnitine in groups A (17.4%) and B (14.4%). In the comparison between the groups, plasma L-carnitine was higher in group A than B in 10º (p = 0.024), 30º (p = 0.001), and 60º postoperative day (p = 0.008). Supplementation of L-carnitine at a daily oral dose of 50 mg / kg in patients with heart failure undergoing coronary artery bypass grafting may recover preoperative plasma L-carnitine within 10 days |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Cirugía, Falla cardiaca, Isquemia, Revascularización miocárdica, L-carnitina, Suplementación |
| Keyword: | Cardiovascular system, Surgery, Heart failure, Ischemia, Myocardial revascularization, L-carnitine, Supplementation |
| Texte intégral: | Texto completo (Ver HTML) |
