| Revue: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436316 |
| ISSN: | 0001-3765 |
| Autores: | Spera, Kamille D1 Figueiredo, Patrícia A1 Santos, Pamela C.E1 Barbosa, Fernando C1 Alves, Caio P1 Dokkedal, Anne Lígia2 Saldanha, Luiz Leonardo2 Silva, Luciana P3 Figueiredo, Carlos Rogério4 Ferreira, Paulo Cesar1 Silva, Regildo M.G. da1 |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias e Letras de Assis, Assis, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias, Bauru, Sao Paulo. Brasil 3Fundacao Educacional do Municipio de Assis, Assis, Sao Paulo. Brasil 4Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil |
| Año: | 2019 |
| Volumen: | 91 |
| Número: | 4 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic extract from H. courbaril seeds. Therefore, for the cytotoxicity test an anti-melanoma assay was performed in B16F10 strain cells. The genotoxicity and antigenotoxicity was evaluated in bone marrow cells (Permit number: 002/2010) of mice, the antioxidant activity was determined by the DPPH test and the total flavonoid content was also determined. The hydroethanolic extract showed antigenotoxic effect and antioxidant activity. It was verified that total flavonoid content was 442.25±18.03 mg RE/g dry extract. HPLC-PAD chromatogram revealed presence of flavones as majority compound in evaluated extract. The results allowed us to also infer that the hydroethanolic extract from seeds shows cytotoxic activity against B16F10 melanoma cells line and it has dose-and-time-dependency |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Farmacología, Oncología, Plantas medicinales, Extractos vegetales, Semillas, Bioensayos, Genotoxicidad, Actividad antioxidante, Actividad antineoplásica, Hymenaea courbaril, Caesalpinaceae |
| Keyword: | Pharmacology, Oncology, Medicinal plants, Plant extracts, Seeds, Bioassays, Genotoxicity, Antioxidant activity, Antineoplastic activity, Hymenaea courbaril, Caesalpinaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
