Revue: | Anais da Academia Brasileira de Ciencias |
Base de datos: | PERIÓDICA |
Número de sistema: | 000417628 |
ISSN: | 0001-3765 |
Autores: | Zeni, Ana Lucia B1 Moreira, Tatianne D1 Dalmagro, Ana Paula1 Camargo, Anderson2 Bini, Larissa A2 Simionatto, Edesio L1 Scharf, Dilamara R1 |
Instituciones: | 1Universidade Regional de Blumenau, Departamento de Quimica, Blumenau, Santa Catarina. Brasil 2Universidade Regional de Blumenau, Departamento de Ciencias Naturais, Blumenau, Santa Catarina. Brasil |
Año: | 2017 |
Periodo: | Dic |
Volumen: | 89 |
Número: | 4 |
Paginación: | 2085-2816 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Morus nigra L. (Moraceae) is a tree known as black mulberry and the leaves are used in folk medicine in the treatment of diabetes, high cholesterol and menopause symptoms. The aim of this study was to evaluate the M. nigra leaves phytochemical profile in different extractions and the hypolipidemic effect of the infusion comparing to the fenofibrate. Morus nigra infusion (MN) showed higher amounts of phenolics and flavonoids (83.85 mg/g and 79.96 µg/g, respectively), as well as antioxidant activity (83.85%) than decoction or hydromethanolic extracts. Although, decoction showed the best result for ascorbic acid (4.35 mg/100 g) than hydromethanolic or infusion (2.51 or 2.13 mg/100 g, respectively). The phenolic acids gallic, chlorogenic and caffeic and the flavonoids quercetin, rutin and catechin were found in the M. nigra extracts. Hyperlipidemic rats treated with 100, 200 or 400 mg/kg of MN decreased serum cholesterol, triglycerides and normalized lipoproteins. Furthermore, MN inhibited lipid peroxidation in liver, kidney and brain of hyperlipidemic rats. This study provides evidence that M. nigra leaves extracts are rich in polyphenols, mainly chlorogenic acid, which normalized hyperlipidemic disturbance. The results suggest a potential therapeutic effect of the M. nigra leaves infusion on dislipidemic condition and related oxidative stress |
Disciplinas: | Medicina, Química |
Palabras clave: | Fitoquímica, Farmacología, Angiospermas, Extractos vegetales, Hojas, Compuestos fenólicos, Actividad lipolítica, Morus nigra |
Keyword: | Phytochemistry, Pharmacology, Angiosperms, Plant extracts, Leaves, Phenolic compounds, Lipolytic activity, Morus nigra |
Texte intégral: | Texto completo (Ver HTML) |