| Revue: | Acta scientiarum. Health science |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000366075 |
| ISSN: | 1679-9291 |
| Autores: | Bazzo, Giovana Carolina1 Tambosi, Gabriela1 Bruske, Elizabeth Cristina1 Zetola, Melissa1 Pezzini, Bianca Ramos1 |
| Instituciones: | 1Universidade da Regiao de Joinville, Departamento de Farmacia, Joinville, Santa Catarina. Brasil |
| Año: | 2013 |
| Periodo: | Ene-Jun |
| Volumen: | 35 |
| Número: | 1 |
| Paginación: | 91-96 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Praziquantel is the drug of choice for the treatment of schistosomiasis, however, its low water solubility may undermine the oral bioavailability. In this study, praziquantel was incorporated into microspheres prepared with poly(3-hydroxybutyrate) (PHB) and a polymethacrylate (Eudragit® E), using an emulsion-solvent evaporation method, in order to improve its aqueous solubility. Microparticles prepared with PHB had spherical shape and encapsulation efficiency of 78%. When prepared with Eudragit® E/PHB at a ratio of 50/50 the microspheres were porous and encapsulated 42% of the drug, and for a ratio of 75/25 the microspheres were more porous than those of the previous formulations, with an encapsulation efficiency of 52%. Dissolution in vitro led to a significant improvement in the aqueous solubility of praziquantel incorporated into Eudragit® E/PHB 75/25 microspheres. This increased solubility is linked to the high porosity of the microspheres and the use of Eudragit® E as a hydrophilic carrier |
| Resumen en portugués | Praziquantel is the drug of choice for the treatment of schistosomiasis, however, its low water solubility may undermine the oral bioavailability. In this study, praziquantel was incorporated into microspheres prepared with poly(3-hydroxybutyrate) (PHB) and a polymethacrylate (Eudragit® E), using an emulsion-solvent evaporation method, in order to improve its aqueous solubility. Microparticles prepared with PHB had spherical shape and encapsulation efficiency of 78%. When prepared with Eudragit® E/PHB at a ratio of 50/50 the microspheres were porous and encapsulated 42% of the drug, and for a ratio of 75/25 the microspheres were more porous than those of the previous formulations, with an encapsulation efficiency of 52%. Dissolution in vitro led to a significant improvement in the aqueous solubility of praziquantel incorporated into Eudragit® E/PHB 75/25 microspheres. This increased solubility is linked to the high porosity of the microspheres and the use of Eudragit® E as a hydrophilic carrier |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Química farmacéutica, Parasitología, Antiparasitarios, Praziquantel, Microencapsulación, Solubilidad, Poli(3-hidroxibutirato), Eudragit |
| Keyword: | Medicine, Chemistry, Medicinal chemistry, Parasitology, Antiparasitic agents, Praziquantel, Microencapsulation, Solubility, Poly(3-hydroxybutyrate), Eudragit |
| Texte intégral: | Texto completo (Ver PDF) |
