| Revue: | Acta cirurgica brasileira |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000285967 |
| ISSN: | 0102-8650 |
| Autores: | Neto, J.A.D1 Martins, A.C.P Pastorello, M.T Tucci-Junior, S Suaid, H.J Cologna, A.J |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Medicina, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2001 |
| Volumen: | 16 |
| Paginación: | 91-94 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | We investigate the immunoexpression of MIB-1 antigen on the outcome of the transitional carcinoma of the bladder. We revised 90 patients with a mean follow-up of 55 (2-231) months. Forty five (50%) tumors were grade I, 29 (32.2%), grade II and 16 (17.8%) grade III. The tumors were staged in pTa-1: 62 (68.9%) and pT2-4: 28 (31.1%). We considered positive the tumors with more than 10% imunostained cells. Sixty three patients (70%) expressed MIB-1, with significant difference (P <0,05) between invasive tumors (pT2-4) and non-invasive (pTA-1) and between pTA and pT1 tumors (P=0,01). There was also a significant association of MIB-1 immunostaining with tumor grade: G1 versus G2 (p < 0,001) and G1 versus G3 (p < 0,001). But such difference did not occur with G2 and G3 tumors ( p = 0,2). The relationship of MIB-1 expression with the size of the lesion was significant (p <0,02). The recurrence was not predicted by the MIB-1 labeling pattern (p=0,86), though, the MIB-1-positive patients had significant smaller metastasis free intervals (p = 0.04), and lower survival rates, both among superficial tumors (p=0.009) and in total sample (p = 0.0002) |
| Resumen en portugués | alta expressão do MIB-1 e os estádios invasivos, os graus avançados e os tumores maiores, contudo, não há diferença em tumores recidivados. O índice de positividade do MIB-1 não distinguiu os pacientes com menor tempo livre da doença, foi, contudo, significante para apontar aqueles com menor sobrevida e tempo livre de metástase |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Oncología, Carcinoma, Vejiga, Células transicionales, Inmunohistoquímica, Pronóstico, Sobrevivencia |
| Keyword: | Medicine, Diagnosis, Oncology, Carcinoma, Bladder, Transitional cells, Immunohistochemistry, Prognosis, Survival |
| Texte intégral: | Texto completo (Ver HTML) |
