| Revue: | Acta cirurgica brasileira |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000286164 |
| ISSN: | 0102-8650 |
| Autores: | Mizuma, E.K1 Takeshita, M.S Suaid, Haylton Jorge Martins, Antonio Carlos Pereira Tucci-Junior, Silvio Cologna, Adaulto Jose Goncalves, M.A |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Medicina, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2003 |
| Volumen: | 18 |
| Paginación: | 24-27 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | BACKGROUND: The oxybutynin is an anticholinergic agent that binds to muscarinic receptors of bladder muscle promoting an antispasmodic effect. As a consequence there is an increase in bladder capacity, reduction in frequency and a blockade in the initial stimuli of miction. OBJECTIVE: To verify the action of oxybutynin on bladder overactivity due to hemorrhagic cystitis. METHODS: Hemorrhagic cystitis was provoked through an intraperitoneal injection of 200mg/kg of cyclophosphamide in 10 female rats, weighting 200-250g, 24h before the experiment. The control group of 5 female rats received an intraperitoneal injection of 0.5ml of saline. In the experiment the animals were anesthetized with 1.25mg/kg of urethane followed by a cystostomy with a P-50 catheter connected in Y to an infusion pump (rate of infusion - 0.3ml/min) and to a polygraph to register bladder pressure. The parameters studied were: frequency of bladder contraction (Fc), contraction intensity (Ci), time of bladder filling (Tf) and contraction (Tc), and vesical capacity (Vc) (Tf x flow). We determined the mean value for each parameter following of 10min of observation. After these determinations all rats received 71mg/kg of oxybutynin chloride through nasogastric tubing and 1h afterward the measures were repeated. The data were compared with the Kruskal-Wallis test considering significant a p<0.05. RESULTS: A comparison both groups (control versus experimental) before the use of oxybutynin showed the following values of p: Fc - 0.007; Ci - 0.0002; Tf - 0.768; Tc - 0.492; Vc - 0.055. After the use of oxybutynin the corresponding values were: Fc - p=0.055; Ci - p=0.0002; Tf - 0.957; Tc - p=0.181; Vc - p=0.206. CONCLUSION: The oxybutynin chloride was able to control bladder overactivity expressed by a significant reduction in frequency, but no changes in other parameters |
| Resumen en portugués | Te x Fluxo. Esses parâmetros foram determinados por suas médias durante o período de observação de 10 min. Após o registro, foi infundido por gavagem 71 mg/kg de cloridato de oxibutinina. Uma hora depois foi feita nova cistometria. A análise estatística foi feita pelo método de Kruskal-Wallis que comparou os valores do grupo controle com o experimental. O p foi considerado significante quando menor que 0,05. Resultados: A comparação entre os dois grupos dos parâmetros estudados antes da infusão do cloridrato de oxibutinina mostrou: Fc – p=0,007; Ic – p=0,0002; Te – p=0,768; Tc – p=0,492; Cv – p=0,056 A comparação dos parâmetros estudados depois da droga mostrou: Fc – p= 0,055; Ic – p=0,0002; Te – p=0,957; Tc – p=0,181; Cv – p=0,206. Conclusões: O cloridrato de oxibutinina nesse modelo experimental atuou de forma a alterar somente a freqüência das miccções, controlando a hiperatividade e não promovendo alterações nos demais parâmetros estudados |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Medicina experimental, Nefrología, Bioquímica, Cistitis, Poliaquiuria, Oxibutinina, Ciclofosfamida |
| Keyword: | Medicine, Chemistry, Experimental medicine, Nephrology, Biochemistry, Cystitis, Oxybutynin, Cyclophosphamide, Polyakiuria |
| Texte intégral: | Texto completo (Ver PDF) |
