| Revista: | Veterinaria México OA |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000439060 |
| ISSN: | 2007-5472 |
| Autores: | Sánchez, Diana1 Sánchez Verin, Rogelio2 Corona, Hortensia1 Gutiérrez, Angelina1 Núñez Ochoa, Luis1 Paredes, Jesús1 Cesarman Maus, Gabriela3 |
| Instituciones: | 1Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, Ciudad de México. México 2Hospital Español, Departamento de Patología, Ciudad de México. México 3Instituto Nacional de Cancerología, Departamento de Hematología, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Abr-Jun |
| Volumen: | 6 |
| Número: | 2 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Nota breve o noticia |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Non-Hodgkin’s lymphomas are common canine cancers with variable demographic and clinical presentations. Their pathological characterization and treatment lag far behind those of humans. We describe consecutive lymphoma patients detected over a one-year period at the National Autonomous University of Mexico (UNAM). Of 4,512 dogs: 220 (4.9%) had a cancer diagnosis, of which 27 (0.6%) had lymphoma (12% of cancer patients). We found an association with Miniature Schnauzers, which represented 18.5% (5/27) of lymphoma patients, but it was only 6.4% (288/4,512) of the dogs studied in this time period (p< 0.011). Miniature Schnauzers and mongrels together constituted nearly half of lymphoma cases. Mean age at diagnosis was 7.5 years (3-14), with a female to male ratio of 1.7:1. We found no correlation between lymphoma and castration status. Most patients presented nodal involvement (80%), were in advanced stages III/IV (90%) and had B-cell versus T-cell tumors (64%/36%). Only two histopathological patterns were seen, both with diffuse nodal-replacement by large immunoblast and/or centroblast-like cells; one having numerous tingible-body macrophages which are suggestive of a high proliferative rate. Chemotherapy was given to 15 patients (65%) with an overall response of 73% (3 complete responses/8 partial responses) and a mean overall survival of 219 days (4-586; SD±185). One cutaneous lymphoma-patient achieved partial response (PR) with lomustine/prednisone, and treatment was still ongoing at 548 days. Earlier diagnosis, better lymphoma subtype distinction, and specific curative treatments are needed |
| Disciplinas: | Medicina veterinaria y zootecnia |
| Palabras clave: | Pequeñas especies, Perros, Cáncer, Linfoma canino, Análisis estadístico, Histopatología, Tratamiento |
| Keyword: | Companion animals, Cancer, Canine lymphoma, Statistical analysis, Histopathology, Treatment, Dogs |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
