| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290685 |
| ISSN: | 1413-8670 |
| Authors: | Kiffer, Carlos R.V1 Santos, Sigrid S Machado, Flavia Ribeiro2 Barone, Antonio A |
| Institutions: | 1Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 2Universidade de Sao Paulo, Departamento de Doencas Infecciosas, Sao Paulo. Brasil |
| Year: | 2001 |
| Season: | Jun |
| Volumen: | 5 |
| Number: | 3 |
| Pages: | 124-129 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | This study aimed at evaluating the efficacy and safety of meropenem as first choice treatment for nosocomial pneumonia (NP) in intensive care units (ICU) in Hospital das Clínicas (HC) - University of São Paulo; a hospital with high incidence of antimicrobial resistance. Prospective, open, and non-comparative trial with meropenem were done in patients with ventilator-associated or aspiration NP in 2 ICUs at HC - University of São Paulo. Etiologic investigation was done through bronchoalveolar lavage and blood cultures prior to study entry. Twenty-five (25) critically ill patients with NP were enrolled (mean age 40 years). Ventilator-acquired pneumonia was responsible for 76% of cases and aspiration NP for 24%. Specific etiologic agents were identified and considered to be clinically and temporally responsible for NP in 11 (44%) patients. A. baumanii was responsible for 6 cases (55%), P. aeruginosa for 3 (27%), and S. aureus for 2 (18%). At completion of treatment, 19 patients (76%) showed either cure (48%) or improvement (28%) after use of meropenem therapy. Mortality was 12% at the end of therapy (8% after excluding 1 non-evaluable patient). After 4 to 6 weeks of follow-up, 12 (48%) patients had improved or been totally cured, and overall mortality was 24%. Clinical complications were observed in 11 patients (44%), with none of them definitely related to the study drug. Meropenem as monotherapy was effective and well-tolerated in most NP patients in our ICU. The low mortality rate in this study might have been due to first ... |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Hospitales, Neumología, Meropenema, Neumonía nosocomial, Unidad de cuidados intensivos |
| Keyword: | Medicine, Hospitals, Pharmacology, Pneumology, Meropenem, Nosocomial pneumonia, Intensive care unit (ICU) |
| Full text: | Texto completo (Ver HTML) |
