| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290644 |
| ISSN: | 1413-8670 |
| Authors: | Badaro, Roberto1 Lobo, Iza Nakatani, Maria Muiños, Alvaro M. Netto, Eduardo Coler, Rhea N Reed, Steven G |
| Institutions: | 1Hospital Universitario Prof. Edgar Santos, Unidade Docente Assistencial de Infectologia, Salvador, Bahia. Brasil |
| Year: | 2001 |
| Season: | Ago |
| Volumen: | 5 |
| Number: | 4 |
| Pages: | 223-232 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Immunotherapy has been proposed as a method to treat mucosal leishmaniasis for many years, but the approach has been hampered by poor definition and variability of antigens used, and results have been inconclusive. We report here a case of antimonial-refractory mucosal leishmaniasis in a 45 year old male who was treated with three single injections (one per month) with a cocktail of four Leishmania recombinant antigens selected after documented hypo-responsiveness of the patient to these antigens, plus 50mg of GM-CSF as vaccine adjuvant. Three months after treatment, all lesions had resolved completely and the patient remains without relapse after two years. Side effects of the treatment included only moderate erythema and induration at the injection site after the second and third injections. We conclude that carefully selected microbial antigens and cytokine adjuvant can be successful as immunotherapy for patients with antimonial-refractory mucosal leishmaniasis |
| Disciplines: | Medicina, Biología |
| Keyword: | Terapéutica y rehabilitación, Inmunología, Parasitología, Leishmaniasis, Inmunoterapia, Leishmaniasis mucosa |
| Keyword: | Medicine, Biology, Therapeutics and rehabilitation, Immunology, Parasitology, Leishmaniasis, Immunotherapy, Mucosal leishmaniasis |
| Full text: | Texto completo (Ver HTML) |
