Hospital-associated funguria: analysis of risk factors, clinical presentation and outcome



Document title: Hospital-associated funguria: analysis of risk factors, clinical presentation and outcome
Journal: The brazilian journal of infectious diseases
Database: PERIÓDICA
System number: 000290653
ISSN: 1413-8670
Authors: 1
2
3

Institutions: 1Universidade Federal do Parana, Departamento de Medicina Interna, Curitiba, Parana. Brasil
2Universidade Federal do Parana, Section of Infectious Diseases, Curitiba, Parana. Brasil
3Universidade Federal do Parana, Laboratorio de Micología, Curitiba, Parana. Brasil
Year:
Season: Dic
Volumen: 5
Number: 6
Pages: 313-318
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Caso clínico, analítico
English abstract Fungal urinary tract infections are an increasing problem in hospitalized patients. Funguria may be a result of contamination of the urine specimen, colonization of the urinary tract, or may be indicative of true invasive infection. In this study, we report the risk factors, clinical features, treatments and outcome in a group of 68 hospitalized patients (adults and children) with fungal isolates recovered from 103 urinary samples. Underlying medical conditions were present in most patients. In the pediatric group, urinary tract abnormalities (86%) and prematurity (19%) accounted for the majority of the cases. Diabetes mellitus (28%), nephrolithiasis, and benign prostatic hyperplasia were the most common diseases in adults. Indwelling urethral catheters were noted in 38% of the pediatric patients and in 43% of adults during hospitalization. Candida albicans strains were responsible for 97% and 75% of positive cultures in children and adults, respectively. Symptoms such as fever, dysuria, frequency and flank pain were generally absent in both groups. Fluconazole was the most frequent antifungal utilized (61%) in children and ketoconazole in the adult group (42%). Removing the urinary catheter was attempted in 6 pediatric patients (29%) and in only 8 adults (17%). One patient (4%) in the pediatric group died compared to 10 in the adult group (21%, p=0.04). Successful diagnosis and treatment of funguria depends on a clear understanding of the risk factors and awareness of fungal epidemiology
Disciplines: Biología,
Medicina
Keyword: Hongos,
Diagnóstico,
Nefrología,
Infecciones fúngicas,
Candida albicans,
Funguria,
Candiduria,
Vías urinarias
Keyword: Biology,
Medicine,
Fungi,
Diagnosis,
Nephrology,
Fungal infections,
Candida albicans,
Funguria,
Candiduria,
Urinary tract
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