| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290710 |
| ISSN: | 1413-8670 |
| Authors: | Atomiya, Angela Naomi1 Uip, David Everson Leite, Olavo Henrique Munhoz |
| Institutions: | 1Casa da AIDS clinica, Sao Paulo. Brasil |
| Year: | 2002 |
| Season: | Feb |
| Volumen: | 6 |
| Number: | 1 |
| Pages: | 29-39 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | Patterns of disease, diagnosis, treatment and prognosis of tuberculosis in 100 patients co-infected with AIDS at Casa da AIDS clinic was studied. Demographic characteristics were as follows: 76 male patients, 24 female patients, 67 caucasian, average 35.8 years-old (SD ± 8.5). Sexual transmission of HIV was reported in 68 patients. Pulmonary tuberculosis was seen in 40 patients, extrapulmonary in 11, and combined in 49 patients. In 63 patients, TCD4+ counts were below 200/mm³ when tuberculosis was diagnosed. Fifty-five patients had their diagnoses confirmed by bacteriological identification of Mycobacterium; either through direct observation and/or culture. Tuberculosis was treated with rifampin, isoniazid and pyrazinamide in 60 patients, reinforced treatment in 14 and alternative treatment in the other 13 patients. Tuberculosis therapy lasted up to 9 months in 66% of the patients. Fifty-four patients were treated with a two-drug antiretroviral regimen and the remaining 46 patients received a triple regimen, which included a protease inhibitor. Among the latter, 35 patients were co-treated with rifampin. The occurrence of hepatic liver enzyme abnormalities was statistically related to alternative antiretroviral regimens (p = 0.01) and to the co-administration of rifampin and protease inhibitor (p = 0.019). Clinical resolution of tuberculosis was obtained in 74 patients. Twelve patients died during tuberculosis treatment. Resolution of tuberculosis was statistically significant related to antituberculosis treatment adherence (p = 0 |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Neumología, Inmunología, SIDA, Tuberculosis, Rifampin, Isoniazida, Pirazinamida |
| Keyword: | Medicine, Pharmacology, Pneumology, AIDS, Tuberculosis, Rifampin, Isoniazid, Pyrazinamide, Immunology |
| Full text: | Texto completo (Ver HTML) |
