| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290810 |
| ISSN: | 1413-8670 |
| Authors: | Pedral-Sampaio, Diana Brasil1 Alves, Carmosina R2 Netto, Eduardo Martins1 Brites, Carlos1 Oliveira, Adriano S2 Badaro, Roberto1 |
| Institutions: | 1Universidade Federal da Bahia, Hospital Universitario Prof. Edgard Santos, Salvador, Bahia. Brasil 2Secretaria da Saude do Estado da Bahia, Centro de Referencia Estadual de AIDS, Salvador, Bahia. Brasil |
| Year: | 2004 |
| Season: | Jun |
| Volumen: | 8 |
| Number: | 3 |
| Pages: | 211-216 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Forty-nine AIDS patients, most of who were antiretroviral therapy (ARV) naïve, with active tuberculosis, were treated with Rifampin 600mg, Isoniazid 400mg and Pirazinamide 2g daily. They also received ARV, consisting of Efavirenz (600mg/day) plus 2 NRTIs. All patients were prospectively followed for at least 24 months. Baselines were: male/female ratio 2:1, mean age 34.7 ± 9.4 yrs; weight 51 ± 9.0 kg, viral load 5.6 ± 0.6 logs, CD4 cell count 101 ± 128 cells/ mm3. Follow up mean values of data logs of VL and CD4+ cell /mm3 counts were: VL 1.7 and CD4+ 265; VL 1.3 and CD4+ 251; VL 1.4 and CD4+ 326 at 6, 12 and 24 months, respectively. Weight gain changes were: 5 ± 9.9 ± 12 and 21 ± 16 kg respectively at 6, 12 and 24 months. A non-concomitant ARV regimen was introduced at least three weeks after TB treatment initiation. Severe adverse reactions included rash (two), toxic hepatitis (six), Immune Reconstitution Syndrome (seven), and four deaths. We conclude that Efavirenz at a daily dose of 600 mg is sufficient and safe to treat HIV/TB patients using a Rifampin containing regimen |
| Disciplines: | Medicina |
| Keyword: | Neumología, Terapéutica y rehabilitación, Inmunología, Tuberculosis, VIH, Interacción medicamentosa, Rifampicina, Efavirenz, Terapia antirretroviral |
| Keyword: | Medicine, Pneumology, Therapeutics and rehabilitation, Tuberculosis, HIV, Drug interaction, Rifampin, Efavirenz, Antiretroviral therapy, Immunology |
| Full text: | Texto completo (Ver HTML) |
