| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290675 |
| ISSN: | 1413-8670 |
| Authors: | Llanos-Cuentas, A1 Campos, P Clendenes, M Canfield, C.J2 Hutchinson, D.B.A3 |
| Institutions: | 1Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Lima. Perú 2Pharmaceutical Systems Inc, Talent, Oregon. Estados Unidos de América 3Glaxo Wellcome Research and Development, Londres. Reino Unido |
| Year: | 2001 |
| Season: | Abr |
| Volumen: | 5 |
| Number: | 2 |
| Pages: | 67-72 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15) or 1,500 mg chloroquine (base) over a 3 day period (n=14) (phase 1). The cure rate with chloroquine was lower than expected and patients were subsequently randomized to receive a single dose of 75 mg pyrimethamine and 1,500 mg sulfadoxine (n=9) or atovaquone/proguanil as before (n=5) (phase 2). In phase 1, atovaquone/proguanil was significantly more effective than chloroquine (cure rate 100% [14/14] versus 8% [1/13], P<0.0001). In phase 2, atovaquone/proguanil and pyrimethamine/sulfadoxine were both highly effective (cure rates 100% [5/5] and 100% [7/7]). There were no significant differences between treatment groups in parasite or fever clearance times. Adverse events were typical of malarial symptoms and did not differ significantly between groups. Overall efficacy of atovaquone/proguanil was 100% for treatment of acute falciparum malaria in a region with a high prevalence of chloroquine resistance |
| Disciplines: | Medicina, Biología |
| Keyword: | Farmacología, Salud pública, Protozoarios, Medicamentos, Paludismo, Malarone, Atovacuona, Proguanil, Resistencia a fármacos, Cloroquina, Plasmodium falciparum |
| Keyword: | Medicine, Biology, Pharmacology, Public health, Protozoa, Drugs, Malaria, Malarone, Atovaquone, Proguanil, Chloroquine, Drug resistance, Plasmodium falciparum |
| Full text: | Texto completo (Ver HTML) |
