| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290737 |
| ISSN: | 1413-8670 |
| Authors: | Badaro, Roberto1 Molinar, Fernando Seas, Carlos Stamboulian, Daniel Mendonca, Joao Massud, Joao Nascimento, Luiz Olympio |
| Institutions: | 1Universidade Federal da Bahia, Hospital Prof. Edgar Santos, Salvador, Bahia. Brasil |
| Year: | 2002 |
| Season: | Oct |
| Volumen: | 6 |
| Number: | 5 |
| Pages: | 206-218 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | The safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated. In an open-label, multicenter study, 317 patients with an Acute Physiology and Chronic Health Evaluation (APACHE II) score ranging from >5 to =19 were enrolled with documented pneumonia (n=196), urinary tract infection (n=65), intra-abdominal infection (n=38), or sepsis (n=18). Patients were randomly assigned 1:1 to receive cefepime 1 to 2 g IV twice daily or three times a day or IV ampicillin, cephalothin, or ceftriaxone ± aminoglycoside therapy for 3 to 21 days. For both treatment groups, metronidazole, vancomycin, or macrolide therapy was added as deemed necessary. The primary efficacy variable was clinical response at the end of therapy. Two hundred ninety-six (93%) patients met evaluation criteria and were included in the efficacy analysis. Diagnoses included the following: 180 pneumonias (90 cefepime, 90 comparator), 62 urinary tract infections (29 cefepime, 33 comparator), 37 intra-abdominal infections (19 cefepime, 18 comparator), and 17 sepses (8 cefepime, 9 comparator). At the end of therapy, overall clinical success rates were 131/146 (90%) for patients treated with cefepime vs 125/150 (83%) for those treated with comparator (95% confidence interval [CI]: - 2.6% to 16.3%). The clinical success rate for patients with community-acquired pneumonia, the most frequent infection, was 86% for both treat |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Microbiología, Terapéutica y rehabilitación, Cefepima, Ampicilina, Caphalotin, Infecciones, Vías urinarias, Sepsis |
| Keyword: | Medicine, Microbiology, Pharmacology, Therapeutics and rehabilitation, Cefepime, Ampicillin, Caphalotin, Infections, Urinary tract, Sepsis |
| Full text: | Texto completo (Ver HTML) |
