Journal: | Revista médica del Instituto Mexicano del Seguro Social |
Database: | PERIÓDICA |
System number: | 000335405 |
ISSN: | 0443-5117 |
Authors: | Hernández Morales, Ana Laura1 Zonana Nacach, Abraham1 Zaragoza Sandoval, Víctor Manuel1 |
Institutions: | 1Instituto Mexicano del Seguro Social, Hospital General Regional 20, Tijuana, Baja California. México |
Year: | 2009 |
Season: | Sep-Oct |
Volumen: | 47 |
Number: | 5 |
Pages: | 497-503 |
Country: | México |
Language: | Español |
Document type: | Artículo |
Approach: | Experimental, aplicado |
Spanish abstract | Objetivo: determinar factores de riesgo asociados a leucemia aguda en niños. Métodos: se incluyeron 47 niños con leucemia aguda y 47 controles sanos pareados por sexo, edad ± 3 años y residencia. Se investigaron antecedentes sociodemográficos, heredofamiliares, ginecoobstétricos, perinatales, tabaquismo, alcoholismo, exposición a campos magnéticos y uso de pesticidas. Resultados: la edad fue de 7.2 ± 4.4 años. Existió mayor riesgo si se usó plaguicidas en casa (RM = 2.1, IC 95 % = 1.5-2.9) o jardín (RM = 1.8, IC 95 % = 1.2-2.6) tres meses antes del embarazo. En los casos se observó mayor frecuencia (no significativa) de pérdida fetal previa (14.9 versus 6.4 %), ictericia neonatal (14.9 versus 4.3 %), consumo de tabaco por la madre tres meses previos al embarazo (23.4 versus 10.6 %), consumo de alcohol por el padre (80 versus 68 %), uso de plaguicidas durante el embarazo en casa (21 versus 8.5 %) o jardín (8.5 versus 2.1%,) y cercanía de la residencia (< 60 m) a campos agrícolas (23.4 versus 12.8 %). Conclusiones: el uso de plaguicidas antes del embarazo en casa o jardín continúa siendo uno factor de riesgo posiblemente asociado a leucemia aguda en niños |
English abstract | Objective: to investigate the risk factors associated with childhood acute leukemia (CHAL). Methods: during a year period 47 prevalent and incidental cases with CHAL and 47 controls (healthy children) were included. They were matched by gender, age (± 3 years) and residence area. Sociodemographic, gyneco-obstetric, perinatal features, parents’ use of alcohol or smoking, exposure to electromagnetic fields and exposure to pesticides 3 months before and during pregnancy were assessed. Associations were assessed using odds ratios (OR) with 95 % confidence intervals (CI). Results: the average age was 7.2 ± 4.4 years; 61.7 % were male. An increased OR was found for domestic (OR = 2.1, CI 95 = % 1.5-2.9) or garden (OR = 1.8, IC 95 % = 1.2-2.6) use of pesticides three months before pregnancy. A non-significant frequency was observed with previous fetal death, neonatal jaundice, smoking 3 months before pregnancy, father intake of alcohol, pesticides use during pregnancy at home or garden and living close (< 60 m) to agricultural fields. Conclusions: the domestic or garden use of pesticides three months before pregnancy may play a role in the etiology of CHAL |
Disciplines: | Medicina |
Keyword: | Hematología, Oncología, Pediatría, Leucemia aguda, Factores de riesgo, Plaguicidas |
Keyword: | Medicine, Hematology, Oncology, Pediatrics, Acute leukemia, Pesticides |
Full text: | Texto completo (Ver HTML) |