| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000455005 |
| ISSN: | 0034-9887 |
| Authors: | Arratia, Gabriel1 San Martín, Fernanda1 Brkljaca, Nicolás1 Agüero, Claudia2 Vergara, Maximiliano1 Guzmán, Ana María1 |
| Institutions: | 1Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile 2Red de Salud UC-Christus, Santiago de Chile. Chile |
| Year: | 2022 |
| Season: | Jun |
| Volumen: | 150 |
| Number: | 6 |
| Pages: | 832-835 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Multiple Myeloma (MM) is characterized by a clonal expansion of plasma cells in the bone marrow. These cells typically produce a monoclonal immunoglobulin, and its symptoms arise either from plasma cell infiltration in several organs, or secondary to the presence of a monoclonal protein peak. Symptoms can be summarized by the acronym CRAB (hypercalcemia, renal failure, anemia and bone lesions). Sometimes, in the setting of a protein secreting monoclonal gammopathy, formation of cryoglobulins develops. Cryoglobulins are plasma proteins that precipitate at low temperatures, forming a cold - induced precipitate at small vessels, causing a wide range of clinical manifestations. We report a female consulting for ulcers lasting 2 months in the left foot associated with purpuric lesions in both lower limbs. Protein electrophoresis showed a monoclonal peak in the gamma region. Bone marrow aspirate showed 27% of plasma cells with kappa chain restriction by cytometry. The presence of cryoglobulins was confirmed. The patient was treated with dexamethasone and bortezomib, with a progressive healing of lower limb lesions and disappearance of cryoglobulins. She was discharged in good conditions |
| Disciplines: | Medicina |
| Keyword: | Hematología, Crioglobulinemia, Crioglobulinas, Mieloma múltiple, Vasculitis sistémica |
| Keyword: | Hematology, Cryoglobulinemia, Cryoglobulins, Multiple myeloma, Systemic vasculitis |
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