| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000385281 |
| ISSN: | 0034-9887 |
| Authors: | Figueroa, Catalina1 Droppelmann, Katherine1 Quiñones, Verónica1 Amigo, Ludwig1 Mendoza, Camila1 Serrano, Valentina1 Véjar, Margarita1 Maiz, Alberto1 Rigotti, Attilio1 |
| Institutions: | 1Pontificia Universidad Católica de Chile, Santiago de Chile. Chile |
| Year: | 2015 |
| Season: | Sep |
| Volumen: | 143 |
| Number: | 9 |
| Pages: | 1097-1104 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Experimental, caso clínico |
| English abstract | Plasma high density lipoproteins (HDL) are involved in reverse cholesterol transport mediated by the scavenger receptor class B type I (SR-BI). Nicotinic acid increases HDL cholesterol levels, even though its specific impact on SR-BI dependent-cellular cholesterol transport remains unknown. Aim: To determine the effect of nicotinic acid on HDL particle functionality in cholesterol efflux and uptake mediated by SR-BI in cultured cells in hypoalphalipoproteinemic patients. Material and Methods: In a pilot study, eight patients with low HDL (≤ 40 mg/dL) were treated with extended release nicotinic acid. HDL cholesterol and phospholipid levels, HDL2 and HDL3 fractions and HDL particle sizes were measured at baseline and post-therapy. Before and after nicotinic acid treatment, HDL particles were used for cholesterol transport studies in cells transfected with SR-BI. Results: Nicotinic acid treatment raised total HDL cholesterol and phospholipids, HDL2 levels as well as HDL particle size. Nicotinic acid significantly increased HDL cholesterol efflux and uptake capacity mediated by SR-BI in cultured cells. Conclusions: Nicotinic acid therapy increases SR-BI-dependent HDL cholesterol transport in cultured cells, establishing a new cellular mechanism by which this lipid-lowering drug appears to modulate HDL metabolism in patients with hypoalphalipoproteinemia |
| Disciplines: | Medicina |
| Keyword: | Metabolismo y nutrición, Biología celular, Acido nicotínico, Colesterol, Lipoproteínas de alta densidad, Niacina |
| Keyword: | Medicine, Metabolism and nutrition, Cell biology, Nicotinic acid, Cholesterol, High density lipoproteins, Niacin |
| Full text: | Texto completo (Ver HTML) |
