| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000394555 |
| ISSN: | 0034-9887 |
| Authors: | Wenshuai Li1 Yanyun Ma2 Deqing Zeng1 Jun Zhang1 Rui Wang1 Jingyi Hu1 Dongqin Yang1 Heping Hu3 Jiucun Wang2 Jie Liu1 |
| Institutions: | 1Fudan University, Huashan Hospital, Shanghai. China 2Fudan University, School of Life Sciences, Shanghai. China 3Second Military Medical University, Eastern Hepatobiliary Surgery Hospital, Shanghai. China |
| Year: | 2016 |
| Season: | Abr |
| Volumen: | 144 |
| Number: | 4 |
| Pages: | 508-515 |
| Country: | Chile |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, analítico |
| Spanish abstract | El carcinoma hepatocelular (CHC) tiene una alta morbilidad y mortalidad. Polimorfismos de un nucleótido (SNP) presentes en el microRNA (miRNA) circulante pueden asociarse a ciertos tumores. Objetivo: Estudiar la asociación entre la presencia de SNPs en miRNA circulante y la presencia de carcinoma hepatocelular. Material y Métodos: Se determinó la presencia de tres SNP en microRNA de sangre periférica en 498 pacientes con CHC y 520 controles. Resultados: El SNP rs13299349 en el miRNA3152 se asoció con CHC. El genotipo AA o el alelo A se asociaron con un riesgo mayor de presentar un CHC. El alelo A se asoció además con el tamaño y número de focos del tumor. Se observó también una relación entre el SNP rs10061133 en el miRNA449b y HCC. En este caso, el alelo G se relacionó con un mayor riesgo de CHC. Conclusiones: Los SNP rs13299349 en el miRNA3152 y rs10061133 en el miRNA449b se asocian al riesgo de desarrollar CHC |
| English abstract | Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors. Aim: To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material and Methods: Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls. Results: A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele. Conclusions: This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Oncología, Genética, Carcinoma hepatocelular, Biomarcadores, MicroARNs, Polimorfismo genético, Diagnóstico temprano |
| Keyword: | Medicine, Gastroenterology, Oncology, Genetics, Hepatocellular carcinoma, Biomarkers, MicroRNAs, Genetic polymorphism, Early diagnosis |
| Full text: | Texto completo (Ver HTML) |
