| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000431085 |
| ISSN: | 0034-9887 |
| Authors: | López Vidal, Hernán1 Peña, Camila1 Gajardo, Claudia1 Valladares, Ximena1 Cabrera, María Elena2 |
| Institutions: | 1Hospital del Salvador, Sección de Hematología, Santiago de Chile. Chile 2Universidad de Chile, Facultad de Medicina, Santiago de Chile. Chile |
| Year: | 2019 |
| Season: | Jul |
| Volumen: | 147 |
| Number: | 7 |
| Pages: | 836-841 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Autoimmune hemolytic anemia (AIHA) is an uncommon disease. In its presentation, it can be severe and even lethal. There is only one clinical report concerning this pathology in Chile. Objective: To describe the clinical characteristics and evolution of adult AIHA inpatients. Materials and Methods: Retrospective review of clinical records of adult AIHA inpatients between January 2010 and June 2018 was done. Demographic, clinical, laboratory and therapeutic information was analyzed. A descriptive, analytical and survival analysis was performed. Results: Forty-three adult patients diagnosed with AHIA were hospitalized in a period of 8 years. Median age was 63 years (range 22-86 years), mostly women (72%). Warm antibodies were detected in 36 cases (84%) and cold antibodies in seven. Seventy two percent of the patients had an underlying cause, and 58% were secondary to lymphoproliferative neoplasms. All patients except two, received steroids as initial treatment, with response in 37 (90%) of them. Three refractory patients received rituximab, with response in all of them, and relapse in one. Median follow-up was 38 months (range 2-98 months). Five year overall survival was 72%. Conclusion: AHIA in adults inpatients is a heterogeneous disease, mainly due to warm antibodies, and to secondary etiology |
| Disciplines: | Medicina |
| Keyword: | Hematología, Inmunología, Enfermedades autoinmunes, Autoanticuerpos, Anemia hemolítica autoinmune, Rituximab |
| Keyword: | Hematology, Immunology, Autoimmune diseases, Autoantibodies, Autoimmune hemolytic anemia, Rituximab |
| Full text: | Texto completo (Ver HTML) |
