The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
Document title: The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
Journal: Revista do Instituto de Medicina Tropical de Sao Paulo
Database:
System number: 000547875
ISSN: 0036-4665
Authors: 1
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Institutions: 1Universidade de São Paulo, Faculdade de Medicina, São Paulo, São Paulo. Brasil
Year:
Volumen: 64
Country: Brasil
Language: Inglés
English abstract Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
Keyword: Retroviruses,
HIV,
HTLV-1,
HERVs,
Interferon-γ,
Immune regulation
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