| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547846 |
| ISSN: | 0036-4665 |
| Authors: | Cardoso, Claudete Aparecida Araújo1 Rossoni, Andrea Maciel de Oliveira2 Rezende, Joana Moraes de3 Aurilio, Rafaela Baroni3 Santos, Roberta Jaime Ferreira Lima dos3 Ferrarini, Maria Aparecida Gadiani4 Kritski, Afranio Lineu5 Martin, Anandi6 Sant’Anna, Clemax Couto3 |
| Institutions: | 1Universidade Federal Fluminense, Faculdade de Medicina, Niterói, Rio de Janeiro. Brasil 2Universidade Federal do Paraná, Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Curitiba, Paraná. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, Rio de Janeiro. Brasil 4Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo. Brasil 5Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Rio de Janeiro, Rio de Janeiro. Brasil 6Ghent University, Department of Biochemistry and Microbiology, Ghent. Bélgica |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | This study investigated the potential use of the String Test (ST) for the diagnosis of pulmonary tuberculosis (PTB) in children and adolescents. This is a case series of patients aged 4-15 years presenting with clinically presumed PTB and submitted to ST in three pediatric TB referral centers in Brazil, between November 2017 and July 2020. The ST was performed in the morning, after 4-12 h of fasting, followed by ingestion of the capsule by the patient, which was attached to the patient’s malar region. The material was collected for simultaneous smear microscopy (acid-fast bacilli - AFB), culture and the molecular investigation by the GeneXpert MTB/RIF®. Thirty-three patients with presumed PTB were included and ST was performed in 26 (78.8%) of them and 7 (21.2%) patients could not swallow the cord. The diagnosis of PTB was established in 11 (42.3%) of the 26 patients who underwent the ST. The diagnosis of PTB was confirmed (by culture or GeneXpert MTB/RIF®) in 5 patients, 4 of whom were also positive by the ST. Two of them showed positivity by the GeneXpert MTB/RIF® only in the ST sample. Two other patients had a positive ST following the induced sputum test (AFB, GeneXpert MTB/RIF®, and positive culture in both specimens). Thus, ST was positive in 36.4% of the patients in whom PTB was diagnosed. ST could be a useful test for diagnosing PTB in children and adolescents. |
| Keyword: | Diagnostic techniques and procedures, Pulmonary tuberculosis, Children, String test |
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