| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000537097 |
| ISSN: | 0036-4665 |
| Authors: | Dahy, Flávia Esper1 Novaes, Christina T. G.2 Bandeira, Gabriela A.2 Ramin, Laís F.2 Oliveira, Augusto César Penalva de1 Smid, Jerusa1 |
| Institutions: | 1Instituto de Infectologia Emílio Ribas, São Paulo, São Paulo. Brasil 2Universidade de São Paulo, Hospital das Clínicas, São Paulo, São Paulo. Brasil |
| Year: | 2021 |
| Volumen: | 63 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Human immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly patients. Our objective is to describe two cases of PLHIV presenting with controlled infections and sCJD, and to review the literature. Our patients were younger than expected for sCJD and one of them had a longer disease course. As aging is expected to occur earlier in PLHIV, sCJD must be excluded in younger PLHIV presenting with RPD and without CNS infection. |
| Keyword: | HIV, Dementia, Prion disease, Creutzfeldt-Jakob disease, HAND |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
