| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547853 |
| ISSN: | 0036-4665 |
| Authors: | Mobile, Rafael Zancan1 Warnawin, Stephanie von Stein Cubas1 Kojo, Teresinha Keiko2 Rodrigues, Jéssica Alline Pereira2 Cavilha, Adriana Mendes de Quadros2 Zerbinati, Rodrigo Melim3 Adamoski, Douglas4 Oliveira, Jaqueline Carvalho de4 Conzentino, Marcelo Santos5 Huergo, Luciano Fernandes5 Gradia, Daniela Fiori4 Braz Silva, Paulo Henrique3 Schussel, Juliana Lucena1 |
| Institutions: | 1Universidade Federal do Paraná, Departamento de Estomatologia, Curitiba, Paraná. Brasil 2Universidade Federal do Paraná, Complexo Hospital de Clínicas, Curitiba, Paraná. Brasil 3Universidade de São Paulo, Faculdade de Medicina, São Paulo, São Paulo. Brasil 4Universidade Federal do Paraná, Departamento de Genética, Curitiba, Paraná. Brasil 5Universidade Federal do Paraná, Setor Litoral, Curitiba, Paraná. Brasil 6Universidade de São Paulo, Faculdade de Odontologia, São Paulo, São Paulo. Brasil |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario. |
| Keyword: | COVID-19, SARS-CoV-2, Hematopoietic stem cell transplantation, Healthcare workers |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
