| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547824 |
| ISSN: | 0036-4665 |
| Authors: | Frade, Virgínia Paula1 Moreira, Carlos Henrique Valente2 Sabino, Ester Cerdeira3 Bedor, Danilo César Galindo4 Ghilard, Fábio de Rose2 Oliveira, Cláudia Di Lorenzo1 Sanches, Cristina1 |
| Institutions: | 1Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais. Brasil 2Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo. Brasil 3Instituto de Infectologia Emilio Ribas, São Paulo, São Paulo. Brasil 4Universidade Federal de Pernambuco, Recife, Pernambuco. Brasil |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective cohort study with eight patients diagnosed with Chagas disease during the beginning of BZD treatment up to the 60th day. On the 15th day of treatment, a blood sampling was collected and analyzed. A one-compartment PK model was developed using Pmetrics. Patients with an average age of 50.3 (SD: 6.2) years old, 6 female patients and 2 males, 70.2 kg (14.2), receiving a 5 mg/Kg/day dose were included. PK parameters estimated for CL, V and Ka were 6.27 L/h, 38.97 L and 1.66 h-1, respectively. This is the first study to establish a population pharmacokinetic modeling of BZD in Brazilian patients with chronic Chagas disease. Therefore, further studies are needed to obtain the complete characterization of BZD pharmacokinetics. |
| Keyword: | Chagas disease, Benznidazole, Pharmacokinetic |
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