| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547872 |
| ISSN: | 0036-4665 |
| Authors: | He, Juan1 Liu, Shengyuan2 Guo, Xujun2 Zhang, Fan2 Takiff, Howard Eugene2 Zhao, Yashuang1 |
| Institutions: | 1Harbin Medical University, School of Public Health, Harbin. China 2Shenzhen Nanshan Center for Chronic Disease Control, Department of Tuberculosis Control and Prevention, Shenzhen. China 3Instituto Venezolano de Investigaciones Científicas, CMBC, Caracas. Venezuela |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Although tuberculosis (TB) is a serious public health concern, we still don’t understand why only 10% of people infected will develop the disease. Apoptosis plays a role in the interaction of Mycobacterium tuberculosis (Mtb) with the human host and it may be modified by subtle alterations in the B-cell lymphoma 2 (BCL2) gene, an anti-apoptotic regulatory element. Therefore, we investigated whether there is an association between BCL2 polymorphisms and susceptibility to TB by analyzing 130 TB cases, 108 subjects with latent TB infection (LTBI), and 163 healthy controls (HC). Logistic regression was used to calculate odds ratios (ORs) and 95% confidential intervals (95% CIs) for possible associations between single nucleotide polymorphisms (SNPs) in BCL2 and the risk of tuberculosis. We found that the G allele of rs80030866 (OR=0.62, 95%CI:0.42-0.91, P=0.015), and also the G allele of rs9955190 (OR=0.58, 95%CI:0.38-0.88, P=0.011) were less frequent in the TB group compared with the LTBI group. In addition, individuals with rs2551402 CC genotype were more likely to have LTBI than those with AA genotype (OR=2.166, 95%CI:1.046-4.484, P=0.037). Our study suggests that BCL2 gene polymorphisms may be correlated with susceptibility to both TB and LTBI. |
| Keyword: | Tuberculosis, Susceptibility, Latent tuberculosis infection, BCL2, Polymorphism |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
