| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547826 |
| ISSN: | 0036-4665 |
| Authors: | Neves, Marina Seixas Studart e1 Paiva, José Hícaro Hellano Gonçalves Lima3 Ferreira, Natália Stefani de Assunção3 Queiroz, Francisca Patrícia Almeida1 Limeira, Camilla Bezerra Bastos1 Veras, Camila Monteiro1 Carvalho, Themístocles Mesquita Teles de1 Freitas, Taina Veras de Sandes1 Esmeraldo, Ronaldo de Matos1 Brasil, Ivelise Regina Canito1 |
| Institutions: | 1Hospital Geral de Fortaleza, Departamento de Transplantes, Fortaleza, Ceará. Brasil 2Universidade de São Paulo, Faculdade de Medicina, São Paulo, São Paulo. Brasil 3Universidade Estadual do Ceará, Fortaleza, Ceará. Brasil |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Worldwide, transplant programs have suffered a setback during the coronavirus disease 2019 (COVID-19) pandemic and most have temporarily suspended their transplant activities. . We identified 36 liver transplant patients who tested positive for COVID-19. The cases were confirmed by the nucleic acid test (RT-PCR). Epidemiological, demographic, clinical, laboratory, management and outcome data were obtained from the patients’ medical records. Fourteen patients (38.9%) required admission to the Intensive Care Unit and/or invasive ventilatory support (severe cases). The mean age of these severe cases was 63.8 years. Regarding the time since the transplant, 71.4% (10/14 patients) had undergone the procedure less than one year before. The immunosuppressive therapy was reduced in patients who required Intensive Care Unit. A total of 12 cases (12/14, 85.7%) required invasive ventilatory support. Eight cases (8/14, 57.1%) required renal replacement therapy. In this group of patients, nine died (64.3 %). In turn, 22 patients had mild to moderate symptoms of COVID-19, not requiring invasive ventilatory support or admission to the Intensive Care Unit. The mean age in these patients was 56.5 years and comorbidities were present in 15 (68.2%) of the cases. In this group, only five patients (5/22, 22.7%) required hospitalization due to complications and there were no deaths This report describes the results of COVID-19 infection in a very specific population, suggesting that liver transplant patients have a significant higher risk of progressing to severeCOVID-19 , with a mortality rate among critically-ill patients above that of the general population. |
| Keyword: | Coronavirus infections, Liver transplantation, COVID-19 |
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