Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2
Document title: Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2
Journal: Revista do Instituto de Medicina Tropical de Sao Paulo
Database:
System number: 000537143
ISSN: 0036-4665
Authors: 1
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Institutions: 1Universidade Feevale, Laboratório de Microbiologia Molecular, Novo Hamburgo, Rio Grande do Sul. Brasil
2Secretaria Municipal da Saúde, Campo Bom, Rio Grande do Sul. Brasil
Year:
Volumen: 63
Country: Brasil
Language: Inglés
English abstract Multiple variants of the Severe Acute Respiratory Syndrome coronavirus 2 virus (SARS-CoV-2) have been constantly reported across the world. The B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated the P.1 variant of concern (VOC), recently named as the Gamma variant by the newly WHO nomenclature proposal, and P.2 as a variant of interest (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same male patient was reinfected by another B.1.1.28 variant, namely P.2, in March, 2021. The genomic analysis confirmed genetically significant differences between the two viruses recovered in both infections, the P.1 lineage in the first episode and P.2 in the reinfection. Due the very early detection of P.1, we have also investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, and this variant has disseminated and became prominent from late January to the end of March, 2021. SARS-CoV-2 recent reports of reinfection have raised critical questions on whether and how well a first infection protects against reinfection.
Keyword: Covid-19,
Reinfection,
SARS-CoV-2,
P.1 lineage,
Brazil
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