| Journal: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Database: | |
| System number: | 000547835 |
| ISSN: | 0036-4665 |
| Authors: | Santos, Veridiana Baldon dos1 Stein, Airton Tetelbom2 Barilli, Sofia Louise Santin1 Garbini, Andresa Fontoura1 Almeida, Rafaela Charão de1 Carazai, Daniela dos Reis1 Santos, Fernanda Costa dos1 Lutkmeier, Raquel1 Greve, Isadora Helena1 Klafke, André3 Mussart, Ketlen Monteiro1 Wittke, Estefania Inez3 |
| Institutions: | 1Grupo Hospitalar Conceição, Hospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil 3Grupo Hospitalar Conceição, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2022 |
| Volumen: | 64 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | COVID-19 is a disease whose knowledge is still under construction, high transmissibility, with no consensual treatment available to everyone. Therefore, the identification of patients at higher risk of evolving to the critical form of the disease is fundamental. The study aimed to determine risk factors associated with the severity of COVID-19 in adults patients. This is an observational, retrospective study from a cohort of adult patients with COVID-19 admitted to a public hospital from March to August 2020, whose medical records were evaluated. For the association of possible severity predictors, a Poisson regression was used. The primary outcome was the critical form of the disease (need for admission to the Intensive Care Unit and/or invasive mechanical ventilation). We included 565 patients: mostly men; 55.5% of those who progressed to the critical form of the disease were over sixty years old. Hypertension, diabetes mellitus and obesity were the most frequent comorbidities. There were 39.8% of patients who progressed to the critical form of the disease. The hospital mortality rate was 22.1%, and that of critical patients was 46.7%. The independent factors associated with the severity of the disease were obesity RR = 1.33 (95% CI 1.07 to 1.66; p = 0.011), SpO2/FiO2 ratio ≤ 315 RR = 2.20 (95% CI 1.79 to 2.71; p = 0.000), C-reactive protein > 100 mg/L RR = 1.65 (95% CI 1.33 to 2.06; p = 0.000), and lymphocytes < 1,000/µL RR = 1.44 (95% CI 1.18 to 1.75; p = 0.000). Advanced age and comorbidities were dependent factors strongly associated with the critical form of the disease. |
| Keyword: | COVID-19, SARS-CoV-2, Risk factors, Severity, Cohort study |
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