A real-life study on the impact of direct-acting antivirals in the treatment of chronic hepatitis C in liver transplant recipients at two university centers in Northeastern Brazil
Document title: A real-life study on the impact of direct-acting antivirals in the treatment of chronic hepatitis C in liver transplant recipients at two university centers in Northeastern Brazil
Journal: Revista do Instituto de Medicina Tropical de Sao Paulo
Database:
System number: 000537084
ISSN: 0036-4665
Authors: 1
2
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1
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Institutions: 1Universidade Federal de Pernambuco, Centro de Ciências Médicas, Recife, Pernambuco. Brasil
2Universidade Federal de Pernambuco, Hospital das Clínicas, Recife, Pernambuco. Brasil
3Universidade de Pernambuco, Unidade de Transplante do Fígado, Recife, Pernambuco. Brasil
4Instituto Professor Fernando Figueira de Medicina Integral, Unidade de Transplante Geral, Recife, Pernambuco. Brasil
5Escola de Saúde de Pernambuco, Recife, Pernambuco. Brasil
6Faculdade Maurício de Nassau, Recife. Brasil
7Hospital Oswaldo Cruz, Serviço de Cirurgia Geral, Recife, Pernambuco. Brasil
8European Virus Bioinformatics Center, Jena. Alemania
9Universidade de Pernambuco, Departamento de Cirurgia, Recife, Pernambuco. Brasil
Year:
Volumen: 63
Country: Brasil
Language: Inglés
English abstract The efficacy of direct-acting antivirals (DAAs) in the treatment of chronic hepatitis C (CHC) in liver transplant recipients is poorly understood, and several factors, including immunosuppression, drug interactions, elevated viraemia, and intolerance to ribavirin (RBV), can reduce cure rates. We conducted a real-life study on liver transplant recipients with CHC treated with a combination of sofosbuvir (SOF) and daclatasvir (DCV) or simeprevir (SIM), with or without RBV, followed-up for 12 to 24 weeks. The treatment effectiveness was assessed by determining the sustained virological response (SVR) rates at 12 or 24 weeks after the treatment cessation. Eighty-four patients were evaluated, with a mean age of 63.4 ± 7.4 years, HCV genotype 1 being the most prevalent (63.1%). Nineteen patients (22.7%) had mild fibrosis (METAVIR < F2) and 41 (48.8%) significant fibrosis (METAVIR ≥ F2). The average time between liver transplantation and the start of treatment was 4 years (2.1-6.6 years). The SOF + DCV regimen was used in 58 patients (69%). RBV in combination with DAAs was used in seven patients (8.3%). SVR was achieved in 82 patients (97.6%), and few relevant adverse events could be attributed to DAA therapy, including a patient who stopped treatment due to a headache. There was a significant reduction in ALT, AST, GGT and FA levels, or the APRI index after 4 weeks of treatment, which remained until 12/24 weeks post-treatment. DAA treatment of CHC in liver-transplanted patients achieved a high SVR rate and resulted in the normalization of serum levels of liver enzymes.
Keyword: Chronic hepatitis C,
Direct-acting antiviral,
Liver transplant,
Sofosbuvir,
Effectiveness,
Brazil,
Liver transplant recipient
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