| Journal: | Revista do Colegio Brasileiro de Cirurgioes |
| Database: | PERIÓDICA |
| System number: | 000283558 |
| ISSN: | 0100-6991 |
| Authors: | Rodrigues, Aluizio1 |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Departamento de Cirurgia, Rio de Janeiro. Brasil |
| Year: | 2006 |
| Season: | Jun |
| Volumen: | 33 |
| Number: | 3 |
| Pages: | 189-197 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Revisión bibliográfica |
| Approach: | Descriptivo |
| English abstract | In the treatment of thyroid cancer, the greatest problem existis in tumors that continue to grow or express recurrences, despite surgical, radioidine or t4 supressive therapies. Improved knowledge of the molecular biology of tumors showed that elevated expression of oncogeneses, uncontrolled ativation of tyrosine cinase receptors and their signaling pathways, and inibition of programmed apoptosis are all important factors in the origin and evolution of tumors and their metastasis. The development of therapies targeted against especific molecular deregulation envolved in tumor progression is now been evaluated, with sucess, in various types of cancer. In thyroid cancer, target therapies using drugs, antibodies, genes, and small molecules are in development in preclinical studies and show a potential role in the managment of thyroid cancer, in the future. In this review, some of these studies are discussed |
| Disciplines: | Medicina |
| Keyword: | Oncología, Terapéutica y rehabilitación, Tiroides, Neoplasias, Glándulas endocrinas, Sobrevivencia, Recurrencia, Carcinoma, Cáncer, Inhibidores, Oncogenes |
| Keyword: | Medicine, Oncology, Therapeutics and rehabilitation, Thyroid gland, Neoplasms, Endocrine glands, Survival, Recurrence, Carcinoma, Cancer, Inhibitors, Oncogenes |
| Full text: | Texto completo (Ver HTML) |
