| Journal: | Revista de saude publica |
| Database: | |
| System number: | 000535866 |
| ISSN: | 0034-8910 |
| Authors: | Xavier Ramos, Michelle de Santana1 Martins, Camilla da Cruz1 Souza, Elivan Silva3 Vieira, Graciete Oliveira1 Gomes Filho, Isaac Suzart1 Figueiredo, Ana Claudia Morais Godoy4 Pereira, Maurício Gomes5 Cruz, Simone Seixas da1 |
| Institutions: | 1Universidade Estadual de Feira de Santana, Departamento de Saúde, Feira de Santana, Bahia. Brasil 2Universidade Federal do Recôncavo da Bahia, Centro de Ciências da Saúde, Santo Antônio de Jesus, Bahia. Brasil 3Universidade de Brasília, Faculdade de Ciências da Saúde, Brasília, Distrito Federal. Brasil 4Secretaria de Estado de Saúde do Distrito Federal, Brasilia, DF. Brasil 5Universidade de Brasília, Escola de Medicina, Brasilia, Distrito Federal. Brasil |
| Year: | 2021 |
| Volumen: | 55 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | OBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB: < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care. |
| Keyword: | Infant, Very Low Birth Weight, Infant, Premature, Immunotherapy, Colostrum, Systematic Review |
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