Serum Repressor Element-1 Silencing Transcription Factor Levels in Alzheimer's Patients from a National Institute of Health in Mexico City, Elderly and Young Controls
Document title: Serum Repressor Element-1 Silencing Transcription Factor Levels in Alzheimer's Patients from a National Institute of Health in Mexico City, Elderly and Young Controls
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000453182
ISSN: 0034-8376
Authors: 1
2
3
1
1
Institutions: 1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Laboratorio de Demencias, Ciudad de México. México
2Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Unidad Periférica de Neurociencias, Ciudad de México. México
3Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Laboratorio de Neurobiología Molecular y Celular, Ciudad de México. México
Year:
Season: Ene-Feb
Volumen: 73
Number: 1
Pages: 17-22
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Decreased levels of repressor element-1 silencing transcription (REST) factor in the brain, plasma, and neuron-derived exosomes are associated with Alzheimer’s disease (AD). Objective: The objective of the study was to test the viability of serum REST as a possible blood-based biomarker for AD, comparing serum REST levels in AD patients from a National Institute of Health in Mexico City (with different levels of severity and comorbidities), with elderly controls (EC) and young controls (YC). Methods: We used an enzyme-linked immunosorbent assay to determine serum REST levels in AD patients (n = 28), EC (n = 19), and YC (n = 24); the AD patients were classified by dementia severity and comorbidities (depression and microangiopathy) using clinimetric tests and magnetic resonance imaging. Results: Mean serum REST levels did not differ between AD patients, EC, and YC. The severity of AD and the presence of depression or microangiopathy were not associated with serum REST levels. Conclusion: Our results differ from previously published patterns found for plasma and cerebral REST levels. Free serum REST levels may not be a viable AD blood-based biomarker. (REV INVEST CLIN. 2021;73(1):17-22)
Disciplines: Medicina
Keyword: Neurología,
Diagnóstico,
Envejecimiento,
Biomarcadores,
Enfermedad de Alzheimer,
Demencia,
Factor silenciador restrictivo
Keyword: Neurology,
Diagnosis,
Biomarkers,
Aging,
Alzheimer disease,
Dementia,
Restrictive silencer factor
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