Factors Associated with Development of Acute Kidney Injury After Liver Transplantation



Título del documento: Factors Associated with Development of Acute Kidney Injury After Liver Transplantation
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000452981
ISSN: 0034-8376
Autores: 1
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Instituciones: 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Nefrología y Metabolismo Mineral, Ciudad de México. México
2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicine Interna, Ciudad de México. México
3Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Gastroenterología, Ciudad de México. México
4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Trasplantes, Ciudad de México. México
5Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México
Año:
Periodo: Mar-Abr
Volumen: 74
Número: 2
Paginación: 90-96
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés Background: Early post-liver transplant (LT) acute kidney injury (AKI) has been associated with worse short-term and long-term outcomes, but the incidence and risk factors in our population are unknown. Methods: We designed a prospective, single-center, longitudinal cohort study to determine the incidence of AKI during the immediate postoperative period of LT, and to identify the risk factors associated with AKI after LT. Pre-operative and intraoperative variables were analyzed to determine if there was any correlation with the development of post-operative AKI. Results: Eighty-six patients were included in the final analysis; from them, 45 (52%) developed AKI in the following 30 days after LT. The presence of hepatic encephalopathy prior to LT was the factor most strongly associated with the development of AKI (Relative Risk 3.67, 95% Confidence Interval 1.08-8.95). Other factors associated with AKI development were male gender and a higher serum lactate during surgery. Conclusion: AKI was a frequent complication that significantly worsened the prognosis of LT recipients and was associated with an increased 30-day mortality rate. The presence of hepatic encephalopathy strongly predicted the development of severe AKI
Disciplinas: Medicina
Palabras clave: Nefrología,
Insuficiencia renal,
Trasplante de riñón,
Lesión renal aguda,
Encefalopatía,
Diálisis
Keyword: Nephrology,
Renal failure,
Kidney transplantation,
Acute kidney injury,
Encephalopathy,
Dialysis
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