| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454093 |
| ISSN: | 0034-8376 |
| Autores: | Pérez Navarro, Lucia M1 Valdez Ortiz, Rafael1 Alegría Díaz, Araceli1 Murguía Romero, Miguel2 Jiménez Flores, Rafael2 Villalobos Molina, Rafael2 Mummidi, Srinivas4 Duggirala, Ravindranath4 López Alvarenga, Juan C4 |
| Instituciones: | 1Hospital General de México, Departamento de Nefrología, Ciudad de México. México 2Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, Los Reyes Iztacala, Estado de México. México 3University of Texas Rio Grande Valley, School of Medicine, Edinburg, Texas. Estados Unidos de América |
| Año: | 2020 |
| Periodo: | Mar-Abr |
| Volumen: | 72 |
| Número: | 2 |
| Paginación: | 95-102 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Cardiometabolic risk factors (CMRFs) appear decades before developing chronic kidney disease (CKD) in adulthood. Objective: The objective of the study was to identify the prevalence and association between CMRFs and kidney function in apparently healthy young adults (18-25 years old). Methods: We included 5531 freshman year students. Data collected on CMRFs included central obesity, high body mass index (hBMI >25), blood pressure, glycemia, lipids, uric acid (UA >6.8 mg/dL), and insulin. Glomerular filtration rate (GFR) was estimated by CKD-Epidemiology Collaboration formula. We used logistic regression and a log linear for odds ratio (OR) (95% confidence level) and probabilities. Results: The presence of any CMRF was observed in 78% (4312) of individuals; GFR ≥120/130 mL/min/1.73 m2sc was found in 33%, GFR <90 mL/min/1.73 m2sc in 3%, and proteinuria in 3%. Factors associated with high GFR were hBMI (OR 1.3 [1.14, 1.47]), UA (OR 0.2 [0.15, 0.26]), high-density lipoprotein (HDL) (OR 1.4 [1.2, 1.6]), and insulin resistance (OR 1.3 [1.05, 1.7]). CMRF associated with low GFR was UA (OR 1.8 [1.3, 2.6]), low-density lipoprotein cholesterol (OR 1.66 [1.05, 2.6]), and proteinuria (OR 3.4 [2.07, 5.7]). Proteinuria was associated with high UA (OR 1.59 [1.01, 2.5]) and hypercholesterolemia (OR 1.8 [1.03, 3.18]). The sole presence of hBMI+UA predicted low GFR with p = 0.6 and hBMI+UA+low HDL predicted proteinuria with p = 0.55. Conclusions: CMRFs were highly prevalent among this freshman student population and were associated with proteinuria and GFR abnormalities. Future studies should focus on public health programs to prevent or delay the development of CKD |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Nefrología, Tasa de filtración glomerular, Pruebas de función renal, Riesgo cardiometabólico |
| Keyword: | Cardiovascular system, Nephrology, Cardiometabolic risk, Glomerular filtration rate, Renal function tests |
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