Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony



Document title: Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony
Journal: Revista da Sociedade Brasileira de Medicina Tropical
Database: PERIÓDICA
System number: 000282740
ISSN: 0037-8682
Authors: 1
Institutions: 1Fundacao Oswaldo Cruz, Instituto de Pesquisa Evandro Chagas, Rio de Janeiro. Brasil
Year:
Season: Jul-Ago
Volumen: 39
Number: 4
Pages: 376-378
Country: Brasil
Language: Inglés
Document type: Nota breve o noticia
Approach: Caso clínico, descriptivo
English abstract Two mucocutaneous leishmaniasis cases resistant to therapy are reported here. After the failure of initial therapies (antimony, amphotericin B and/or pentamidine) patients received a low-dose schedule: one ampoule of meglumine antimoniate (405mg of pentavalent antimony [Sb v]) by intramuscular injection, three times a week until complete healing of the lesions. One patient was cured with a total of 30 ampoules in 10 weeks and the other received 36 ampoules in 12 weeks. Both remain clinically cured after one year of follow-up
Portuguese abstract São relatados dois casos de leishmaniose mucocutânea resistentes ao tratamento. Depois das terapêuticas iniciais (antimônio, anfotericina B e/ou pentamidina), os pacientes receberam um esquema alternativo: uma ampola de antimoniato de meglumina (405mg de antimônio pentavalnte [Sb v]) por via intramuscular, três vezes por semana até a cura completa das lesões. Um paciente recebeu um total de 30 ampolas durante 10 semanas e o outro, 36 ampolas durante 12 semanas. Ambos permanecem clinicamente curados até um ano após o tratamento
Disciplines: Biología,
Medicina
Keyword: Parasitología,
Salud pública,
Terapéutica y rehabilitación,
Leishmaniasis,
Resistencia,
Antimonio,
Tratamiento
Keyword: Biology,
Medicine,
Parasitology,
Public health,
Therapeutics and rehabilitation,
Leishmaniasis,
Resistance,
Antimony,
Treatment
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