Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience



Document title: Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
Journal: Revista da Sociedade Brasileira de Medicina Tropical
Database: PERIÓDICA
System number: 000282783
ISSN: 0037-8682
Authors: 1
2
3


Institutions: 1Hospital Eduardo de Menezes, Belo Horizonte, Minas Gerais. Brasil
2Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil
3Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Belo Horizonte, Minas Gerais. Brasil
Year:
Season: Mar-Abr
Volumen: 39
Number: 2
Pages: 146-151
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Descriptivo
English abstract To study characteristics of neurological disorders in HIV/AIDS patients and their relationship to highly active antiretroviral treatment, a cross-sectional study was conducted in an infectious disease public hospital in Belo Horizonte, Brazil, between February 1999 and March 2000. Of the 417 patients enrolled, neurological disease was observed in 194 (46.5%) and a new AIDS-defining neurological event developed in 23.7% of individuals. Toxoplasmosis (42.3%), cryptococcosis meningitis (12.9%) and tuberculosis (10.8%) were the most common causes of neurological complications. The majority (79.3%) of patients were on highly active antiretroviral treatment and these individuals using HAART showed higher CD4 cell counts (p = 0.014) and presented stable neurological disease (p= 0.0001), although no difference was found with respect to the profile of neurological complications. The neurological diseases continue to be a frequent complication of HIV/AIDS and infections are still its main causes in Brazil, even in the highly active antiretroviral treatment era
Portuguese abstract Com o objetivo de estudar as doenças neurológicas em pacientes HIV/AIDS e sua relação com a terapia anti-retroviral altamente ativa, foi realizado estudo transversal em hospital público de doenças infecciosas de Belo Horizonte, Brasil, no período de fevereiro de 1999 a março de 2000. Doença neurológica foi observada em 194 (46,5%) dos 417 indivíduos incluídos e um novo episódio de doença neurológica definidora de AIDS ocorreu em 23,7% pacientes. Toxoplasmose (42,3%), criptococose (12,9%) e tuberculose (10,8%) foram as principais causas de complicações neurológicas. A maioria dos pacientes estava em uso de terapia anti-retroviral altamente ativa (79,3%) e esses indivíduos apresentaram maiores contagens de linfócitos CD4 (p = 0,014) e maior freqüência de doença neurológica clinicamente estável, embora não tenha havido diferença no perfil etiológico das complicações neurológicas. As doenças neurológicas continuam sendo causas freqüentes de complicações da infecção pelo HIV/AIdS no Brasil, e a despeito da terapia anti-retroviral altamente ativa, as infecções são ainda a principal etiologia das doenças do sistema nervoso
Disciplines: Medicina,
Biología
Keyword: Neurología,
Terapéutica y rehabilitación,
Virus,
Brasil,
VIH,
SIDA,
Enfermedades neurológicas,
Terapia antirretroviral
Keyword: Medicine,
Biology,
Neurology,
Therapeutics and rehabilitation,
Virus,
Neurological diseases,
Antiretroviral therapy,
Brazil,
HIV,
AIDS
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