| Journal: | Revista da Sociedade Brasileira de Medicina Tropical |
| Database: | PERIÓDICA |
| System number: | 000282386 |
| ISSN: | 0037-8682 |
| Authors: | Sampaio, Raimunda Nonata Ribeiro1 Takano, Gustavo Henrique Soares Malacarne, Ana Cristina Barbieri Pereira, Tercio Rodrigues Magalhaes, Albino Vercosa de |
| Institutions: | 1Universidade de Brasilia, Faculdade de Medicina, Brasilia, Distrito Federal. Brasil |
| Year: | 2003 |
| Season: | Jul-Ago |
| Volumen: | 36 |
| Number: | 4 |
| Pages: | 531-533 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Nota breve o noticia |
| Approach: | Experimental, analítico |
| English abstract | The efficiency of terbinafine was tested in C57BL/6 mice inoculated with the Leishmania (Leishmania) amazonensis strain MHOM/BR/PH8. The mice were administered: terbinafine at a dose of 100mg/kg/d by via oral; 0.9% saline solution orally as the control; and subcutaneous sodium stibogluconate 400mg SbV/kg/d as gold standard, for 20 days. Terbinafine was demonstrated to be ineffective when compared to the controls, using clinical and parasitological parameters and the limiting dilution assay |
| Portuguese abstract | Testou-se, em camundongos C57BL/6 inoculados com a cepa MHOM/BR/PH8 de Leishmania (Leishmania) amazonensis, terbinafina via oral 100mg/kg/dia, por 20 dias, solução salina 0,9% via oral como controle e stibogluconato de sódio 400mg SbV/kg/dia via subcutânea como padrão-ouro. A terbinafina mostrou-se ineficaz, clínica e parasitologicamente, e pelo ensaio por diluição limitante, quando comparada aos controles |
| Disciplines: | Biología, Medicina |
| Keyword: | Parasitología, Medicina experimental, Terapéutica y rehabilitación, Leishmaniose tegumentar, Terbinafina, Tratamiento, Leishmania amazonensis, Animales de laboratorio, Roedores |
| Keyword: | Biology, Medicine, Parasitology, Experimental medicine, Therapeutics and rehabilitation, Leishmaniasis, Terbinafine, Treatment, Laboratory animals, Rodents, Leishmania amazonensis |
| Full text: | Texto completo (Ver HTML) |
