| Journal: | Revista da Sociedade Brasileira de Medicina Tropical |
| Database: | PERIÓDICA |
| System number: | 000282005 |
| ISSN: | 0037-8682 |
| Authors: | Chapadeiro, Edmundo1 Silva, Eliane Lages Silva, Anita C.M Fernandes, Patricia Ramirez, Luis Eduardo |
| Institutions: | 1Faculdade de Medicina do Triangulo Mineiro, Departamento de Ciencias Biologicas, Uberaba, Minas Gerais. Brasil |
| Year: | 1999 |
| Season: | Ene-Feb |
| Volumen: | 32 |
| Number: | 1 |
| Pages: | 35-39 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The aim of this study was to obtain an experimental animal model of destruction of cardiac neurons in order to investigate the behavior of the cardiac nervous system of hamsters chronically infected with Trypanosoma cruzi. We counted the neuronal cells of the cardiac autonomic nervous plexus in hamsters inoculated with 35 000 blood forms of three different T. cruzi strains and killed 5, 8 and 10 months after infection. We showed for the first time severe neuronal destruction in an experimental animal model with characteristics similar to those observed in human Chagas'disease |
| Portuguese abstract | Com o objetivo de se obter um modelo experimental que permitisse estabelecer a despopulação (desnervação) neuronal cardíaca procurou-se pesquisar o comportamento do sistema nervoso intracardíaco em hamsters cronicamente infectados com o T. cruzi. Para tal fim, realizaram-se contagens dos neurônios do plexo nervoso autonômico intracardíaco em hamsters inoculados com 35.000 formas sangüíneas de três cepas diferentes, sacrificados 5, 8 e 10 meses depois da infecção. Demonstrou-se, pela primeira vez, destruição neuronal significativa num modelo experimental, similar à que ocorre na doença de Chagas humana |
| Disciplines: | Medicina, Biología |
| Keyword: | Neurología, Sistema cardiovascular, Parasitología, Neuronas cardiovasculares, Enfermedad de Chagas, Mesocricetus auratus, Trypanosoma cruzi, Denervación parasimpatética |
| Keyword: | Medicine, Biology, Cardiovascular system, Neurology, Parasitology, Cardiovascular neurons, Chagas disease, Mesocricetus auratus, Trypanosoma cruzi, Parasympathetic denervation |
| Full text: | Texto completo (Ver HTML) |
