| Journal: | Revista da Sociedade Brasileira de Medicina Tropical |
| Database: | PERIÓDICA |
| System number: | 000282821 |
| ISSN: | 0037-8682 |
| Authors: | Moreira, Tomaz de Aquino1 Ferreira, Marcelo Simao2 Ribas, Rosineide Marques Borges, Aercio Sebastiao |
| Institutions: | 1Universidade Federal de Uberlandia, Instituto de Ciencias Biomedicas, Uberlandia, Minas Gerais. Brasil 2Universidade Federal de Uberlandia, Hospital de Clinicas, Uberlandia, Minas Gerais. Brasil |
| Year: | 2006 |
| Season: | May-Jun |
| Volumen: | 39 |
| Number: | 3 |
| Pages: | 255-258 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Descriptivo |
| English abstract | Ninety-six patients with cryptococcosis confirmed by clinical and laboratorial diagnosis were assessed in a prospective study in a University Hospital from March 1998 to November 2003; of these, 81.3% were HIV seropositive patients. Cryptococcus neoformans was isolated from different samples, of which the cerebrospinal fluid 74 (77%) was the most frequent. C. neoformans var neoformans was isolated in 89 cases, where as C. neoformans var gattii was isolated in 7. Cryptococcal meningoencephalitis was detected in 56.3% cases. It was the most frequent unique clinical manifestation and the fungus was detected in the bloodstream in 13.5% of the patients. Among the risk factors, AIDS (81.3%) was the most frequently associated with mycosis. Direct examination carried out on 121 samples revealed the microorganism in 98.3% of them, while the culture was positive for all samples. Most of the patients (59.4%) were treated with amphotericin B or with triazoles, however 72.9% of them ended in death, in particular those patients with positive tests for the HIV (62.5%). Nowadays, cryptococcosis has been frequently diagnosed in our region and represents one of the opportunistic diseases with the highest morbidity and mortality rates in patients with AIDS |
| Portuguese abstract | Estudo prospectivo foi realizado no Hospital de Clínicas da Universidade Federal de Uberlândia, entre março de 1998 e novembro de 2003, em 96 pacientes com diagnóstico clínico e laboratorial de criptococose, sendo 81,3% portadores de Aids. Cepas de Cryptococcus neoformans foram obtidas de diferentes amostras, sendo 77% em líquido cefalorraquidiano. A var neoformans foi isolada em 89 casos e a var gattii em 7. A meningoencefalite criptocócica (56,3% dos casos), foi a manifestação clínica mais descrita, seguida da fungemia (13,5%). Entre os fatores de risco, a AIDS (81,3%) foi o mais comumente associado à micose. A pesquisa direta do fungo realizada em 121 amostras demonstrou o microrganismo em 98,3%, com cultura (+) em todas. Dos pacientes, 59,4% foram tratados com anfotericina B ou derivados triazólicos, sendo que 72,9% evoluíram para óbito, em particular os portadores de AIDS (62,5%). Atualmente, a criptococose tem sido diagnosticada com muita freqüência em nosso meio e constitui uma das doenças oportunísticas de maior morbidade e mortalidade nos pacientes com AIDS |
| Disciplines: | Biología, Medicina |
| Keyword: | Parasitología, Virus, Salud pública, Cryptococcus neoformans, Criptococosis, SIDA, Brasil |
| Keyword: | Biology, Medicine, Parasitology, Virus, Public health, HIV, Cryptococcus neoformans, Cryptococcosis, AIDS, Brazil |
| Full text: | Texto completo (Ver HTML) |
