| Journal: | Revista da Associacao Medica Brasileira |
| Database: | PERIÓDICA |
| System number: | 000307304 |
| ISSN: | 0104-4230 |
| Authors: | Capitani, E.M. de1 Metze, K Frazato Jr., C Altemani, A.M.A Zambom, L Toro, I.F.C Bagatin, E |
| Institutions: | 1Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil |
| Year: | 1997 |
| Season: | Jul-Sep |
| Volumen: | 43 |
| Number: | 3 |
| Pages: | 265-272 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Diffuse Malign Mesotheliomas (DMM) has a low background prevalence. High incidences of this tumor have been related to asbestos exposure in the past. PURPOSE. To describe and discuss three clinical cases treated in our hospital, in which precise histopathologic diagnosis was made, and detailed occupational and environmental histories were taken, trying to identify in their past some kind of asbestos exposure. METHODS. Three cases of DMM are described. Diagnosis was confirmed by histochemical analysis and electronmicroscopy. Detailed occupational and environmental histories were taken from subjects and their families, searching for past contact with asbestos. RESULTS. The cases were diagnosed in a short period of time (two years), in a region of the country where many asbestos cement plants are located since the mid sixties. Skillful histological procedures were used. From these cases we found out that one had a twelve months period of exposure, 24 years before, in one of those plants. Another patient had an exposure for three years, as a bystander, in the same plant (also 24 years before) and a third patient was contaminated by asbestos brought home by his father in the 1950s (latency period of 30 years). All cases were histochemically studied and diagnosis confirmed by the presence of microvilli at electronmicroscopic examination. CONCLUSIONS. These three cases seem to confirm the existence of the epidemiologic association with asbestos exposure in our country. Definition of diagnosis criteria, centralization of cases registry and the necessity of more attention to this kind of asbestos related disease are discussed and stressed, as many new cases like those described are thought to occur in the near future, as the latency period of the disease seems to match with that of industrial asbestos manipulation in Brazil |
| Portuguese abstract | O mesotelioma maligno de pleura (MM) é tumor de ocorrência rara em nosso meio e tem-se mostrado, quando em elevada incidência, relacionado à exposição pregressa a asbesto ou amianto nas séries descritas em outros países. OBJETIVO. A partir de casos clínicos atendidos no Hospital de Clínicas da Unicamp, procurou-se evidenciar tal associação epidemiológica, visando alertar profissionais médicos quanto à possível elevação da incidência de tal tumor nesta década e, futuramente, por características próprias da história natural desse tipo de tumor. MÉTODOS. São descritos três casos de MM de pleura ocorridos na região de Campinas, SP, num período de dois anos, dos pontos de vista clínico, laboratoriais complementares e anatomopatológico, incluindo minuciosa investigação anamnésica ocupacional e ambiental. RESULTADOS. Todos os casos foram confirmados do ponto de vista anatomopatológico, incluindo microscopia eletrônica, como casos de MM. Os três casos mostraram relação epidemiológica, comprovada por meio de história ocupacional, com exposição a asbesto no passado. Um dos casos teve exposição ocupacional pregressa de curta duração (cerca de um ano); outro teve exposição doméstica a partir de asbesto trazido do ambiente de trabalho por seu pai, durante sua infância, e o terceiro caso com contaminação ocupacional indireta. CONCLUSÃO. A ocorrência de MM de pleura relacionada à exposição a asbesto, no passado, parece ser realidade em nosso meio, como mostram estes três casos clínicos. Destaca-se a necessidade da anamnese ocupacional e ambiental |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Neumología, Brasil, Sao Paulo, Campinas, Pulmones, Pleura, Mesotelioma maligno, Asbesto, Etiología |
| Keyword: | Medicine, Diagnosis, Pneumology, Brazil, Sao Paulo, Campinas, Lungs, Pleura, Asbestos, Etiology, Malignant mesothelioma |
| Full text: | Texto completo (Ver HTML) |
