| Journal: | Revista brasileira de reumatologia |
| Database: | PERIÓDICA |
| System number: | 000307130 |
| ISSN: | 0482-5004 |
| Authors: | Carvalho, Monica Martinelli Nunes de1 Giozza, Silvana Pereira Santos, Andre Luiz Muniz Alves dos Carvalho, Edgar Marcelino de Araujo, Maria Ilma |
| Institutions: | 1Universidade Federal da Bahia, Salvador, Bahia. Brasil |
| Year: | 2006 |
| Season: | Sep-Oct |
| Volumen: | 46 |
| Number: | 5 |
| Pages: | 315-322 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | The HTLV-1 is a human retrovirus associated with adult T-cell leukaemia (ATL) and with HTLV-1- associated myelopathy or tropical spastic paraparesis, which has also been implicated in the development of autoimmunity. OBJECTIVE: the aim of this study was to determine the frequency of autoimmune rheumatic diseases in patients infected with HTLV-1. PATIENTS AND METHODS: it was included 137 individuals infected with HTLV-1 from the Multidisciplinary Ambulatory of Immunology Service, HUPES-UFBA, Salvador (BA), from January 2003 to May 2004. All participants answered to a general questionnaire regarding rheumathological manifestations and specific questionnaires to confirm the diagnose criteria of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögrens syndrome (SS) and polymyositis. Additionally, they were submitted to specific clinical exams, besides complementary evaluations. RESULTS: 24 patients had diagnose of probable Sjögrens syndrome (17.5%), 18 patients (13.1%) had RA, one patient had diagnose of SLE (0.7%) and another of mixed connective tissue disease (0.7%, respectively). HTLV-1-associated arthropathy (HAAP) was suspected in 22 individuals (16.1%). Sjögrens syndrome and RA were more frequent in patients with myelopathy (33.3 and 25.9%, respectively) than in asymptomatic carriers (13.6 and 10%, respectively). The frequency of HTLV-1-associated arthropathy was the same in both groups. CONCLUSION: in this study it was observed a high frequency of Sjögrens syndrome and RA in individuals infected with HTLV-1, mainly in those with myelopathy. Therefore, with this results that support data in the literature, we should call attention to the occurrence of autoimmune rheumatic diseases in these kind of patients |
| Portuguese abstract | O HTLV-1 é um retrovírus humano associado à leucemia de células T do adulto e à mielopatia associada ao HTLV-1 ou paraparesia espástica tropical, que tem sido implicado também no desenvolvimento de auto-imunidade. OBJETIVO: o objetivo deste estudo foi determinar a freqüência de doenças reumáticas auto-imunes em pacientes infectados pelo HTLV-1. PACIENTES E MÉTODOS: foram incluídos nesse estudo 137 indivíduos infectados pelo HTLV-1 atendidos no Ambulatório Multidisciplinar do Serviço de Imunologia do Hospital Universitário Professor Edgard Santos (HUPES) da Universidade Federal da Bahia (UFBA), no período de janeiro de 2003 a maio de 2004. Os pacientes responderam a um questionário geral relacionado a manifestações reumatológicas e questionários específicos para confirmação dos critérios diagnósticos de artrite reumatóide (AR), lúpus eritematoso sistêmico (LES), síndrome de Sjögren e polimiosite. Adicionalmente, todos eles foram submetidos a exames clínicos específicos e avaliação complementar. RESUTADOS: 24 pacientes tiveram o diagnóstico de síndrome de Sjögren (SS) provável (17,5%), 18 pacientes (13,1%) de AR, uma paciente teve diagnóstico de LES e uma de doença mista do tecido conjuntivo (0,7%, respectivamente). Suspeita de artropatia relacionada ao vírus foi encontrada em 22 pacientes (16,1%). Síndrome de Sjögren e AR foram mais freqüentes nos pacientes com mielopatia (33,3 e 25,9%, respectivamente) do que nos portadores assintomáticos (13,6 e 10%, respectivamente). Artropatia relacionada ao HTLV-1 ocorreu com freqüê |
| Disciplines: | Medicina |
| Keyword: | Reumatología, Inmunología, HTLV-1, Enfermedades del tejido conjuntivo, Enfermedades autoinmunes, Enfermedades reumáticas |
| Keyword: | Medicine, Rheumatology, Immunology, Connective tissue diseases, Autoimmune diseases, Rheumatic diseases, HTLV-1 |
| Full text: | Texto completo (Ver HTML) |
