Chronic rhinosinusitis in HIV-infected patients: radiological and clinical evaluation
Document title: Chronic rhinosinusitis in HIV-infected patients: radiological and clinical evaluation
Journal: Revista brasileira de otorrinolaringologia
Database: PERIÓDICA
System number: 000306690
ISSN: 0034-7299
Authors: 1
Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil
Year:
Season: Sep-Oct
Volumen: 71
Number: 5
Pages: 604-608
Country: Brasil
Language: Portugués, inglés
Document type: Estadística o encuesta
Approach: Descriptivo
English abstract The advent of protease inhibitors, which enhances the survival rate of HIV-infected individuals, leads patients to search for otorhinolaryngologists, as 40-70% of them may present some sort of otorhinolaryngological disorder. AIM: We aimed at comparing the CT scan findings and the nasosinusal complaints of HIV-infected and AIDS patients with clinical diagnosis of chronic rhinosinusitis. The literature on the subject is revised and discussed. STUDY DESIGN: clinical prospective with transversal cohort. MATERIAL AND METHODS: Prospectively, 39 patients with chronic rhinosinusitis, in use of antiretroviral therapy, were included in the present study and divided into two groups: patients with diagnosis of AIDS (group I) and those infected by HIV (group II). Clinical and laboratorial assessments, with CD4+ cell count and CT evaluation, were performed and compared among groups I and II. RESULTS: Group I and II presented mean CD4+ cell count of 118 cells/10-9l and 377 cells/10-9l, respectively. Comparison of the tomographic findings by the Lund-Mackay staging system presented a score of 12 for group I and 5.63 (pd"0.001) for group II. Fever and postnasal discharge were more prevalent in group I (pd"0.001). CONCLUSIONS: In our Service, prevalence of chronic rhinosinusitis in HIV-infected patients was 12%. AIDS patients had a higher incidence of fever and postnasal discharge than those of group II. Moreover, extensive radiological findings were prevalent in patients with AIDS (group I) than in HIV-infected individuals (group II)
Portuguese abstract O advento dos inibidores de protease, aumentando a sobrevida dos pacientes infectados com HIV aumentou a procura destes pacientes por médicos otorrinolaringologistas, já que 40% a 70% deles podem apresentar alguma alteração otorrinolaringológica. OBJETIVOS: Objetivamos, nesse estudo, comparar os achados radiológicos e sintomatologia nasossinusal entre pacientes infectados com HIV e pacientes com AIDS, com rinossinusite crônica. A literatura sobre o assunto é revisada e discutida. FORMA DE ESTUDO: clínico prospectivo com coorte transversal. CASUÍSTICA E MÉTODOS: Prospectivamente, 39 pacientes em uso de drogas antiretrovirais foram divididos em 2 grupos: pacientes com diagnóstico de AIDS (grupo I) e aqueles apenas infectados pelo HIV (grupo II). Estes grupos foram comparados clinicamente, quanto à contagem de células CD4+ e avaliação tomográfica dos seios paranasais. RESULTADOS: Os pacientes dos grupos I e II apresentaram média de células CD4+ de 118 cél/10-9l e 377 cél/10-9l, respectivamente. Na comparação dos achados tomográficos pelo sistema de Lund e Mackay, o grupo I apresentou escore médio de 12 e o grupo II apresentou média de escore de 5,63 (pd"0.001), sendo a febre e a secreção pós-nasal mais prevalente no grupo I (pd"0.001). CONCLUSÃO: A prevalência da sinusite crônica nos pacientes infectados pelo HIV foi de 12%. Os sintomas da rinossinusite foram similares nos pacientes sem AIDS e com AIDS, com exceção da presença de febre. Os pacientes com AIDS apresentaram alterações radiológicas mais extensas do que os pacientes..
Disciplines: Medicina
Keyword: Otorrinolaringología,
Inmunología,
Rinosinusitis,
VIH,
Síndrome de inmunodeficiencia adquirida (SIDA),
Tomografía computarizada,
Prevalencia
Keyword: Medicine,
Otolaryngology,
Immunology,
Rhinosinusitis,
HIV,
Acquired immunodeficiency syndrome (AIDS),
Computed tomography,
Prevalence
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