| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000199613 |
| ISSN: | 0100-4042 |
| Authors: | Souza, Marcus V.N. de1 Almeida, Mauro V. de |
| Institutions: | 1Universidade Federal de Juiz de Fora, Departamento de Quimica, Juiz de Fora, Minas Gerais. Brasil |
| Year: | 2002 |
| Season: | Ene-Feb |
| Volumen: | 25 |
| Number: | 1 |
| Pages: | 89-98 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Revisión bibliográfica |
| Approach: | Divulgación |
| English abstract | In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products |
| Disciplines: | Química |
| Keyword: | Química orgánica, Piridinas, Ortometalación, Reacciones, Compuestos aromáticos, Compuestos heteroaromáticos |
| Keyword: | Chemistry, Organic chemistry, Pyridines, Ortho metalation, Reactions, Aromatic compounds, Heteroaromatic compounds |
| Full text: | Texto completo (Ver HTML) |
