| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313164 |
| ISSN: | 0100-4042 |
| Authors: | Beck, Ruy Carlos R1 Haas, Sandra Elisa Guterres, Silvia Staniscuaski Re, Maria Ines2 Benvenutti, Edilson V3 Pohlmann, Adriana Raffin |
| Institutions: | 1Universidade Federal do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil 2Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Divisao de Quimica, Sao Paulo. Brasil 3Universidade Federal do Rio Grande do Sul, Instituto de Quimica, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2006 |
| Season: | Sep |
| Volumen: | 29 |
| Number: | 5 |
| Pages: | 990-996 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Nanorrecubrimientos, Nanopartículas, Micropartículas, Tolerancia gastrointestinal, Microparticle |
| Keyword: | Chemistry, Medicinal chemistry, Nanocoatings, Nanoparticles, Microparticles, Gastrointestinal tolerance |
| Full text: | Texto completo (Ver HTML) |
