| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000199540 |
| ISSN: | 0100-4042 |
| Authors: | Reina, Luisa del Carmen Barrett1 Montanari, Carlos Alberto Donnici, Claudio Luis Diogenes, Izaura Cirino Nogueira Moreira, Icaro de Sousa |
| Institutions: | 1Universidade Federal de Minas Gerais, Departamento de Quimica, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal do Ceara, Departamento de Quimica Organica e Inorganica, Fortaleza, Ceara. Brasil |
| Year: | 2002 |
| Season: | Ene-Feb |
| Volumen: | 25 |
| Number: | 1 |
| Pages: | 5-9 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Organosulfur compounds present in garlic and onion have been evaluated as inhibitors of chemical carcinogenesis. Among them diallylsulfide was mainly investigated and studies demonstrated its metabolization to the corresponding sulfoxide and sulfone. In this work, we report the investigation of the interaction between the diallylsulfide and its oxidized derivatives, through cyclic voltammetry, with horse heart cytocrome-c (on a modified electrode with 4-mercaptopyridine). Our results suggest that there is a reversible interaction between cytocrome-c and diallylsulfide and diallylsulfone and an irreversible interaction with the diallylsulfoxide |
| Disciplines: | Química, Medicina |
| Keyword: | Bioquímica, Química analítica, Oncología, Compuestos organosulfurados, Ajo, Citocromo C, Voltametría, Voltametría cíclica, Allium, Cáncer, Cebolla |
| Keyword: | Chemistry, Medicine, Analytical chemistry, Biochemistry, Oncology, Organosulfur compounds, Garlic, Cytochrome C, Voltammetry, Allium, Cancer, Onion |
| Full text: | Texto completo (Ver HTML) |
